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논문 기본 정보

자료유형
학술저널
저자정보
Junbo Feng (First Affiliated Hospital of Anhui Medical University) Haiyuan Liu (Hefei Second People’s Hospital) Jiayi Chen (First Affiliated Hospital of Anhui Medical University) Jiyuan Wang (First Affiliated Hospital of Anhui Medical University) Zhuang Liu (First Affiliated Hospital of Anhui Medical University) Shenglin Ge (First Affiliated Hospital of Anhui Medical University)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.46 No.3
발행연도
2016.1
수록면
402 - 407 (6page)

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Background and Objectives: To explore the lung-protective effect of levosimendan (LS) during cardiopulmonary bypass in a canine modelby determining the wet/dry weight (W/D) ratio of lung tissue, malonaldehyde (MDA) and superoxide dismutase (SOD) concentrations, andperforming a histological evaluation. Materials and Methods: Thirty-two canines were divided randomly into four groups and underwent a routine aortic cross-clampingcardiopulmonary bypass procedure for 1 h, followed by recovery for 2 h. Animals were handled as follows: group C (means controlgroup), no special treatment after aortic cross clamping; group P (means pulmonary artery perfusion group), pulmonary artery perfusionwith cold oxygenated blood after aortic cross clamping; group LSIV (means intravenous injection of LS group), intravenous injection of LS(65 μg/kg) before thoracotomy, and the rest of the procedure was identical to the control group; group LPS (means pulmonary perfusionwith LS group), pulmonary perfusion with cold oxygenated blood combined with LS (65 μg/kg) after aortic cross clamping. Lung tissueswere removed and subjected to evaluation of pathological alterations, W/D ratio and MDA and SOD concentrations. Results: In group C, the W/D ratio and MDA concentration were higher, while the SOD concentrations were lower (p<0.05). Comparedwith groups P and LSIV, the MDA concentration was lower in group LPS, while that of SOD was higher (p<0.05); Light and electronmicroscopy indicated that LS intervention reduced impairment of lung tissues. Conclusion: Our findings suggest that LS plays an important role in protecting lung tissues.

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참고문헌 (14)

참고문헌 신청
Qiu W / 2008 / Comparison between adult and infant lung injury in a rabbit ischemia-reperfusion mode / J Thorac Cardiovasc Surg 136:352~359 google schola Kim JC / 2012 / Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery / Chest 142:467~475 google schola Rong J / 2013 / Receptor for advanced glycation end products involved in lung ischemia reperfusion injury in cardiopulmonary bypass attenuated by controlled oxygen reperfusion in a canine model / ASAIO J 59:302~308 google schola Rong J / 2012 / Controlled oxygen reperfusion protects the lung against early ischemia-reperfusion injury in cardiopulmonary bypasses by downregulating high mobility group box 1 / Exp Lung Res 38:183~191 google schola Wang C / 2012 / Increased matrix metalloproteinase-9activity and mRNA expression in lung injury following cardiopulmonary bypass / Lab Invest 92:910~916 google schola

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