지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.26 No.3
- 발행연도
- 2017.1
- 수록면
- 161 - 171 (11page)
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초록· 키워드
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Obesity is associated with increased risk of developing metabolic diseases such as type 2 diabetes. The origins of obesity are multi-factorial, but ultimately rooted in increased host energy accumulation or retention. The gut microbiota has been implicated in control of host energy balance and nutrient extraction from dietary sources. The microbiota also impacts host immune status and dysbiosis-related inflammation can augment insulin resistance, independently of obesity. Advances in microbial metagenomic analyses and directly manipulating bacterial-host models of obesity have contributed to our understanding of the relationship between gut bacteria and metabolic disease. Foodborne, or drug-mediated perturbations to the gut microbiota can increase metabolic inflammation, insulin resistance, and dysglycemia. There is now some evidence that specific bacterial species can influence obesity and related metabolic defects such as insulin sensitivity. Components of bacteria are sufficient to impact obesity-related changes in metabolism. In fact, different microbial components derived from the bacterial cell wall can increase or decrease insulin resistance. Improving our understanding of the how components of the microbiota alter host metabolism is positioned to aid in the development of dietary interventions, avoiding triggers of dysbiosis, and generating novel therapeutic strategies to combat increasing rates of obesity and diabetes.
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참고문헌 (80)
참고문헌 신청
Sender R / 2016 / Revised estimates for the number of human and bacteria cells in the body / PLoS Biol 14:e1002533
이은주 / 2016 / Pharmacological Management of Obesity in Patients with Type 2 Diabetes: An Update / Journal of Obesity & Metabolic Syndrome 25(3):121~128
류혜진 / 2017 / Body Mass Index and Mortality / Journal of Obesity & Metabolic Syndrome 26(1):3~9
Bäckhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101:15718~15723
Bäckhed F / 2007 / Mechanisms underlying the resistance to diet-induced obesity in germ-free mice / Proc Natl Acad Sci U S A 104:979~984
이은주 / 2016 / Pharmacological Management of Obesity in Patients with Type 2 Diabetes: An Update / Journal of Obesity & Metabolic Syndrome 25(3):121~128
류혜진 / 2017 / Body Mass Index and Mortality / Journal of Obesity & Metabolic Syndrome 26(1):3~9
Bäckhed F / 2004 / The gut microbiota as an environmental factor that regulates fat storage / Proc Natl Acad Sci U S A 101:15718~15723
Bäckhed F / 2007 / Mechanisms underlying the resistance to diet-induced obesity in germ-free mice / Proc Natl Acad Sci U S A 104:979~984
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