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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 351 - 356 (6page)
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Purpose: This study aimed to compare the safety and efficacy of tamsulosin and tadalafil as medical expulsive therapy for distal ureteral stones. Materials and Methods: This prospective randomized study was conducted at the Department of Urology of Bir Hospital over a period of 12 months in patients with distal ureteral stones sized 5 to 10 mm. Patients were randomly divided into 2 groups: group A received tamsulosin 0.4 mg and group B received tadalafil 10 mg at bedtime for 2 weeks. Stone expulsion rate, number of ureteric colic episodes and pain score, analgesic requirements, and adverse drug effects were noted in both groups. Statistical analyses were performed by using Student t-test and chi-square test. Results: Altogether 85 patients, 41 in group A and 44 in group B, were enrolled in the study. The patients' average age was 31.72±12.63 years, and the male-to-female ratio was 1.5:1. Demographic profiles, stone size, and baseline investigations were comparable between the 2 groups. The stone expulsion rate was significantly higher in the tadalafil group than in the tamsulosin group (84.1% vs. 61.0%, p=0.017). Although the occurrence of side effects was higher with tadalafil, this difference was not significant (p=0.099). There were no serious adverse effects. Conclusions: Tadalafil has a significantly higher stone expulsion rate than tamsulosin when used as a medical expulsive therapy for distal ureteral stones sized 5–10 mm. Both drugs are safe, effective, and well tolerated with minor side effects.
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참고문헌 (26)
참고문헌 신청
Pearle MS / 2012 / Campbell-Walsh urology / Saunders Elsevier :1257~1286
Abul-fotouh Abdel-maguid Ahmed / 2010 / Tamsulosin versus Alfuzosin in the Treatment of Patients with Distal Ureteral Stones: Prospective, Randomized, Comparative Study / Investigative and Clinical Urology 51(3):193~197
Ueno A / 1977 / Relation of spontaneous passage of ureteral calculi to size / Urology 10:544~546
Singh SK / 2011 / Medical therapy for calculus disease / BJU Int 107:356~368
Wang CJ / 2008 / Efficacy of an alpha1 blocker in expulsive therapy of lower ureteral stones / J Endourol 22:41~46
Abul-fotouh Abdel-maguid Ahmed / 2010 / Tamsulosin versus Alfuzosin in the Treatment of Patients with Distal Ureteral Stones: Prospective, Randomized, Comparative Study / Investigative and Clinical Urology 51(3):193~197
Ueno A / 1977 / Relation of spontaneous passage of ureteral calculi to size / Urology 10:544~546
Singh SK / 2011 / Medical therapy for calculus disease / BJU Int 107:356~368
Wang CJ / 2008 / Efficacy of an alpha1 blocker in expulsive therapy of lower ureteral stones / J Endourol 22:41~46
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