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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.70 No.2
- 발행연도
- 2017.1
- 수록면
- 203 - 208 (6page)
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초록· 키워드
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Background: Magnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (NMB) during consistent pretreatment of MgSO4 in rabbits. Methods: Twenty-eight rabbits were randomly assigned to four groups, a control group or study groups (50% MgSO4 150–200 mg/kg and 25 mg/kg/h IV), and received rocuronium 0.6 mg/kg. When post-tetanic count 1–2 appeared, sugammadex 2, 4, and 8 mg/kg was administered in the 2-mg group, control and 4-mg group, and 8-mg group, respectively. The recovery course after reversal of sugammadex administration was evaluated in each group. Results: The mean serum concentration of magnesium was maintained at more than 2 mmol/L in the study groups, and the total dose of MgSO4 was more than 590 mg. The reversal effect of sugammadex on rocuronium-induced NMB in pretreated MgSO4 was not different from that in the group without MgSO4. The recovery time to train-of-four ratio 0.9 after sugammadex administration in the 2-mg group was longer than in the other groups (P < 0.001); there were no other significant differences among the groups. Conclusions: The reversal of sugammadex from a deep rocuronium-induced NMB during large pretreatment of MgSO4 was not affected. However, we should consider that the reversal effect of sugammadex varied depending on the dose.
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참고문헌 (29)
참고문헌 신청
Duley L / 2009 / The global impact of pre-eclampsia and eclampsia / Semin Perinatol 33:130~137
Sibai BM / 2005 / Magnesium sulfate prophylaxis in preeclampsia: evidence from randomized trials / Clin Obstet Gynecol 48:478~488
Lee C / 1996 / Electromyographic and mechanomyographic characteristics of neuromuscular block by magnesium sulphate in the pig / Br J Anaesth 76:278~283
Jones RK / 2008 / Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine / Anesthesiology 109:816~824
Kim MH / 2016 / Maintaining optimal surgical conditions with low insufflation pressures is possible with deep neuromuscular blockade during laparoscopic colorectal surgery: a prospective, randomized, double-blind, parallel-group clinical trial / Medicine (Baltimore) 95:e2920
Sibai BM / 2005 / Magnesium sulfate prophylaxis in preeclampsia: evidence from randomized trials / Clin Obstet Gynecol 48:478~488
Lee C / 1996 / Electromyographic and mechanomyographic characteristics of neuromuscular block by magnesium sulphate in the pig / Br J Anaesth 76:278~283
Jones RK / 2008 / Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine / Anesthesiology 109:816~824
Kim MH / 2016 / Maintaining optimal surgical conditions with low insufflation pressures is possible with deep neuromuscular blockade during laparoscopic colorectal surgery: a prospective, randomized, double-blind, parallel-group clinical trial / Medicine (Baltimore) 95:e2920
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