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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.69 No.1
- 발행연도
- 2016.1
- 수록면
- 57 - 62 (6page)
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초록· 키워드
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Background: Lipid emulsions have been used to treat various drug toxicities and for total parenteral nutrition therapy. Their usefulness has also been confirmed in patients with local anesthetic-induced cardiac toxicity. The purpose of this study was to measure the hemodynamic and composition effects of lipid emulsions and to elucidate the mechanism associated with changes in intracellular calcium levels in myocardiocytes. Methods: We measured hemodynamic effects using a digital analysis system after IntralipidⓇ and LipofundinⓇ MCT/ LCT were infused into hearts hanging in a Langendorff perfusion system. We measured the effects of the lipid emulsions on intracellular calcium levels in H9c2 cells by confocal microscopy. Results: Infusion of LipofundinⓇ MCT/LCT 20% (1 ml/kg) resulted in a significant increase in left ventricular systolic pressure compared to that after infusing modified Krebs-Henseleit solution (1 ml/kg) (P = 0.003, 95% confidence interval [CI], 2.4–12.5). LipofundinⓇ MCT/LCT 20% had a more positive inotropic effect than that of IntralipidⓇ 20% (P = 0.009, 95% CI, 1.4–11.6). Both lipid emulsion treatments increased intracellular calcium levels. LipofundinⓇ MCT/LCT (0.01%) increased intracellular calcium level more than that of 0.01% IntralipidⓇ (P < 0.05, 95% CI, 0.0–1.9). Conclusions: These two lipid emulsions had different inotropic effects depending on their triglyceride component. The inotropic effect of lipid emulsions could be related with intracellular calcium level.
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참고문헌 (24)
참고문헌 신청
Warshawsky KY / 1992 / Intravenous fat emulsions in clinical practice / Nutr Clin Pract 7:187~196
Chambrier C / 2004 / Replacement of long-chain triglyceride with medium-chain triglyceride/long-chain triglyceride lipid emulsion in patients receiving long-term parenteral nutrition: effects on essential fatty acid status and plasma vitamin K1 levels / JPEN J Parenter Enteral Nutr 28:7~12
Cave G / 2011 / Intravenous lipid emulsion as antidote: a summary of published human experience / Emerg Med Australas 23:123~141
Rothschild L / 2010 / Intravenous lipid emulsion in clinical toxicology / Scand J Trauma Resusc Emerg Med 18:51
Dix SK / 2011 / Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion / Crit Care Med 39:872~874
Chambrier C / 2004 / Replacement of long-chain triglyceride with medium-chain triglyceride/long-chain triglyceride lipid emulsion in patients receiving long-term parenteral nutrition: effects on essential fatty acid status and plasma vitamin K1 levels / JPEN J Parenter Enteral Nutr 28:7~12
Cave G / 2011 / Intravenous lipid emulsion as antidote: a summary of published human experience / Emerg Med Australas 23:123~141
Rothschild L / 2010 / Intravenous lipid emulsion in clinical toxicology / Scand J Trauma Resusc Emerg Med 18:51
Dix SK / 2011 / Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion / Crit Care Med 39:872~874
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