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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 274 - 280 (7page)
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초록· 키워드
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Background: Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes. Methods: We enrolled 484 patients with diabetes who received statin treatment for more than 12 months. We included patients treated with moderate-intensity dose statin treatment (atorvastatin 10 to 20 mg/day or rosuvastatin 5 to 10 mg/day). The primary outcome was a change in estimated glomerular filtration rate (eGFR) during the 12-month statin treatment, and rapid renal decline was defined as a >3% reduction in eGFR in a 1-year period. Results: In both statin treatment groups, patients showed improved serum lipid levels and significantly reduced eGFRs (from 80.3 to 78.8 mL/min/1.73 m2 for atorvastatin [P=0.012], from 79.1 to 76.1 mL/min/1.73 m2 for rosuvastatin [P=0.001]). A more rapid eGFR decline was observed in the rosuvastatin group than in the atorvastatin group (48.7% vs. 38.6%, P=0.029). Multiple logistic regression analyses demonstrated more rapid renal function loss in the rosuvastatin group than in the atorvastatin group after adjustment for other confounding factors (odds ratio, 1.60; 95% confidence interval, 1.06 to 2.42). Conclusion: These results suggest that a moderate-intensity dose of atorvastatin has fewer detrimental effects on renal function than that of rosuvastatin.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Radhakrishnan J / 2014 / Taming the chronic kidney disease epidemic: a global view of surveillance efforts / Kidney Int 86:246~250
Collins AJ / 2011 / US renal data system 2010 annual data report / Am J Kidney Dis 57(1 Suppl 1):e1~e526
박철휘 / 2014 / Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives / Diabetes and Metabolism Journal 38(4):252~260
안재희 / 2014 / Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey / Diabetes and Metabolism Journal 38(2):109~119
de Zeeuw D / 2015 / Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): a randomised clinical trial / Lancet Diabetes Endocrinol 3:181~190
Collins AJ / 2011 / US renal data system 2010 annual data report / Am J Kidney Dis 57(1 Suppl 1):e1~e526
박철휘 / 2014 / Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives / Diabetes and Metabolism Journal 38(4):252~260
안재희 / 2014 / Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey / Diabetes and Metabolism Journal 38(2):109~119
de Zeeuw D / 2015 / Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): a randomised clinical trial / Lancet Diabetes Endocrinol 3:181~190
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