Comparison of Fixed versus Calculated Activity of Radioiodine for the Treatment of Graves Disease in Adults

Abigail U. Canto; Paulette N. Dominguez; Cecilia A. Jimeno; Jerry M. Obaldo; Ruben V. Ogbac

추천

검색

자료유형: 학술저널

저자정보: Abigail U. Canto (University of the Philippines) Paulette N. Dominguez (University of the Philippines) Cecilia A. Jimeno (University of the Philippines) Jerry M. Obaldo (University of the Philippines) Ruben V. Ogbac (University of the Philippines)

저널정보: 대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.31 No.1

발행연도: 2016.1

수록면: 168 - 173 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Radioactive iodine as a treatment modality has been shown in several studies to be a safe and effective therapy for Graves disease. However, there is still no uniformity regarding optimal dosing method. The aim of this study is to compare the efficacy of calculated and fixed dosing of radioiodine for the treatment of Graves disease. Methods: A hundred twenty-two patients diagnosed with Graves disease were randomized to receive either fixed or calculated dose of radioiodine. Those randomized to fixed activity received either low fixed activity at 9.9 mCi for thyroid gland size <40 g or high fixed activity at 14.9 mCi for thyroid gland size 40 to 80 g, and those grouped to calculated activity received 160 µCi/g of thyroid tissue adjusted for 24 hours radioiodine uptake. Thyroid function tests (free thyroxine [T4] and thyroid stimulating hor mone [TSH]) were monitored at 10, 16, and 24 weeks after radioactive iodine therapy. The primary outcome, treatment failure was defined as persistently elevated free T4 and low TSH. Results: Of the 122 patients randomized, 56 in the fixed dose group and 56 in the calculated dose group completed the follow up. At the end of 6 months, the percentage of treatment failure was 37.50% in the calculated dose group versus 19.64% in the fixed dose group with a relative risk of 0.53 (95% confidence interval, 0.28 to 0.98) favoring the fixed dose group. Conclusion: Fixed dose radioiodine has a significantly lower incidence of persistent hyperthyroidism at 6 months post-radioac tive therapy.

참고문헌 (12)

참고문헌 신청

Leslie WD / 2003 / A randomized comparison of radioiodine doses in Graves’ hyperthyroidism / J Clin Endocrinol Metab 88:978~983

de Rooij A / 2009 / Clinical outcomes after estimated versus calculated activity of radioiodine for the treatment of hyperthyroidism : systematic review and meta-analysis / Eur J Endocrinol 161:771~777

DeGroot LJ / 2010 / Endocrinology: adult and pediatric / Saunders :3525

Sisson JC / 2007 / Radioiodine treatment of hyperthyroidism: fixed or calculated doses ; intelligent design or science? / Eur J Nucl Med Mol Imaging 34:1129~1130

Bahn Chair RS / 2011 / Hyperthyroidism and other causes of thyrotoxicosis : management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists / Thyroid 21:593~646

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!