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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 247 - 254 (8page)
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초록· 키워드
오류제보하기
Soft corals are a remarkable group of marine organisms, containing diverse array of secondary metabolites with biofunctional properties. The purpose of this study was to evaluate the potential theraputic properties of the ethanol extracts of soft coral collected from the Jeju Island against lipopolysaccharide (LPS) stimulated macrophage inflammation. The ethanol extracts of the soft corals Dendronephthya gigantea, Dendronephthya puetteri, Dendronephthya aurea, Scleronephthya gracillimum, and Chromonephthea hirotai exhibited more significantly inhibitory effects against nitric oxide (NO) generation stimulated by LPS in macrophages compared to the others. Moreover, these extracts significantly decrease the expression of interleukin-1 beta (IL- 1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and prostaglandin E2 (PGE2). Moreover, they also suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) could be observed. With further investigation, these soft corals could potentially provide the insight to develop anti-inflammatory compounds with clinical applications.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Suleria, H. A. R / 2016 / Marine bioactive compounds and health promoting perspectives; Innovation pathways for drug discovery / Trend Food Sci. Tech 50:44~55
Leal, M. C / 2016 / Natural products discovery needs improved taxonomic and geographic information / Nat. Prod. Rep 33:747~750
Haefner, B / 2003 / Drugs from the deep: Marine natural products as drug candidates / Drug Discov. Today 8:536~544
Smit, A. J / 2004 / Medicinal and pharmaceutical uses of seaweed natural products: A review / J. Appl. Physiol 16:245~262
Hou, R.-S / 1995 / Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinularia gibberosa / J. Nat. Prod 58:1126~1130
Leal, M. C / 2016 / Natural products discovery needs improved taxonomic and geographic information / Nat. Prod. Rep 33:747~750
Haefner, B / 2003 / Drugs from the deep: Marine natural products as drug candidates / Drug Discov. Today 8:536~544
Smit, A. J / 2004 / Medicinal and pharmaceutical uses of seaweed natural products: A review / J. Appl. Physiol 16:245~262
Hou, R.-S / 1995 / Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinularia gibberosa / J. Nat. Prod 58:1126~1130
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