지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 381 - 386 (6page)
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초록· 키워드
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The effect of exercise, which increases hippocampal neurogenesis and improves memory function, is well documented, however, differences in the effect of exercise on young children and adults are not yet known. In the present study, age-dependent differences of treadmill ex-ercise on spatial learning ability between young- and adult-age rats were investigated. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 6 weeks. Radial 8-arm maze test was conducted for the determination of spatial learning abili-ty. Cell proliferation in the hippocampal dentate gyrus was determined by 5-bromo-2′-deoxyuridine immunohistochemistry. Western blot for brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) was performed. In the present study, the number of errors in the young-age rats was effectively decreased by treadmill exercise. Hippocampal neurogenesis was more active in the young-age rats than in the adult-age rats. BDNF and TrkB expression in the hippocampus was greater in the adult-age rats than in the young-age rats. The results of this study showed that adults have excellent spatial learning abilities than chil-dren, but the improvement of exercise-induced spatial learning ability through neurogenesis is better in children.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Baek SS / 2012 / Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups / Brain Dev 34:45~56
Baym CL / 2014 / Aerobic fitness predicts relational memory but not item memory performance in healthy young adults / J Cogn Neurosci 26:2645~2652
Calabrese F / 2009 / Neuronal plasticity: a link between stress and mood disorders / Psychoneuroendocrinology 34(Suppl 1):S208~S216
Chaddock L / 2010 / A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children / Brain Res 1358:172~183
Chen L / 2006 / Effects of exercise on neurogenesis in the dentate gyrus and ability of learning and memory after hippocampus lesion in adult rats / Neurosci Bull 22:1~6
Baym CL / 2014 / Aerobic fitness predicts relational memory but not item memory performance in healthy young adults / J Cogn Neurosci 26:2645~2652
Calabrese F / 2009 / Neuronal plasticity: a link between stress and mood disorders / Psychoneuroendocrinology 34(Suppl 1):S208~S216
Chaddock L / 2010 / A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children / Brain Res 1358:172~183
Chen L / 2006 / Effects of exercise on neurogenesis in the dentate gyrus and ability of learning and memory after hippocampus lesion in adult rats / Neurosci Bull 22:1~6
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