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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,385 - 1,395 (11page)
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We estimated the effect of various immunosuppressants (ISs) and metformin (M) to provide theoretical background of optimal therapeutic strategy for de novo colon cancer after liver transplantation (LT). Three colon cancer cell lines (HT29, SW620, and HCT116) were used in in vitro studies. HT29 was also used in BALB/c-nude mice animal models. Following groups were used in both in vitro and in vivo studies: sirolimus (S), tacrolimus (T), cyclosporin A (CsA), M, metformin/sirolimus (Met/S), metformin/tacrolimus (Met/T), and metformin/cyclosporin A (Met/CsA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed and western blot analyses were performed for mTOR pathway proteins, apoptosis proteins, and epithelial-mesenchymal-transition (EMT) proteins. Tumor volume was measured for 4 weeks after inoculation. MTT-assay revealed significant cell viability inhibition in all 3 colon cancer cell lines in groups of S, M, and Met/S. Of note, group Met/S showed synergistic effect compare to M or S group. Western blot analysis showed significant low levels of all investigated proteins in groups of S and Met/S in both in vitro and in vivo experiment. Tumor growth was significantly inhibited only in the Met/S group. Combination of Met and S showed the most potent inhibition in all colon cancer cell lines. This finding might have application for de novo colon cancer.
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참고문헌 (34)
참고문헌 신청
Doycheva I / 2016 / De novo malignancies after transplantation : risk and surveillance strategies / Med Clin North Am 100:551~567
Mukthinuthalapati PK / 2016 / Incidence, risk factors and outcomes of de novo malignancies post liver transplantation / World J Hepatol 8:533~544
Jain A / 2008 / Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up / Liver Transpl 14:1406~1411
Vallejo GH / 2005 / Incidence and risk factors for cancer after liver transplantation / Crit Rev Oncol Hematol 56:87~99
Tiao GM / 2005 / The current management of hepatoblastoma: a combination of chemotherapy, conventional resection, and liver transplantation / J Pediatr 146:204~211
Mukthinuthalapati PK / 2016 / Incidence, risk factors and outcomes of de novo malignancies post liver transplantation / World J Hepatol 8:533~544
Jain A / 2008 / Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up / Liver Transpl 14:1406~1411
Vallejo GH / 2005 / Incidence and risk factors for cancer after liver transplantation / Crit Rev Oncol Hematol 56:87~99
Tiao GM / 2005 / The current management of hepatoblastoma: a combination of chemotherapy, conventional resection, and liver transplantation / J Pediatr 146:204~211
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