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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,662 - 1,663 (2page)
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Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. A 39-year-old man was referred to emergency room for loss of consciousness and dyspnea after taking of PEG-3350 (Colyte®). In laboratory findings, the initial serum tryptase level was increased to 91.9 mg/L (normal range: 0.00-11.40 mg/L) without any other laboratory abnormalities. The intradermal test with 10 mg/mL Colyte® showed a 5×5 mm wheal, but basophil activation and histamine releasability tests were negative. PEG-3350 is widely used as an osmotic laxative due to its lack of absorption from the gastrointestinal tract. However, the loss of mucosal integrity at gastrointestinal membrane such as diverticulitis may be a predisposing factor for anaphylaxis to Colyte®. We report a case of anaphylaxis induced by the ingestion of PEG-3350 in a patient with diverticulitis which might be a risk factor of anaphylaxis.
목차
등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
Knop K / 2010 / Poly(ethylene glycol)in drug delivery : pros and cons as well as potential alternatives / Angew Chem Int Ed Engl 49:6288~6308
Sun Hee Lee / 2015 / Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol / Intestinal research 13(1):90~94
Wenande EC / 2013 / Inhibition of polyethylene glycol-induced histamine release by monomeric ethylene and diethylene glycol : a case of probable polyethylene glycol allergy / J Allergy Clin Immunol 131:1425~1427
Chanan-Khan A / 2003 / Complement activation following first exposure to pegylated liposomal doxorubicin(Doxil) : possible role in hypersensitivity reactions / Ann Oncol 14:1430~1437
Almer S / 1993 / Increased absorption of polyethylene glycol 600 deposited in the colon in active ulcerative colitis / Gut 34:509~513
Sun Hee Lee / 2015 / Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol / Intestinal research 13(1):90~94
Wenande EC / 2013 / Inhibition of polyethylene glycol-induced histamine release by monomeric ethylene and diethylene glycol : a case of probable polyethylene glycol allergy / J Allergy Clin Immunol 131:1425~1427
Chanan-Khan A / 2003 / Complement activation following first exposure to pegylated liposomal doxorubicin(Doxil) : possible role in hypersensitivity reactions / Ann Oncol 14:1430~1437
Almer S / 1993 / Increased absorption of polyethylene glycol 600 deposited in the colon in active ulcerative colitis / Gut 34:509~513
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