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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,273 - 1,278 (6page)
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Capsular fibrosis and contracture occurs in most breast reconstruction patients who undergo radiotherapy, and there is no definitive solution for its prevention. Simvastatin was effective at reducing fibrosis in various models. Peri-implant capsular formation is the result of tissue fibrosis development in irradiated breasts. The purpose of this study was to examine the effect of simvastatin on peri-implant fibrosis in rats. Eighteen male Sprague- Dawley rats were allocated to an experimental group (9 rats, 18 implants) or a control group (9 rats, 18 implants). Two hemispherical silicone implants, 10 mm in diameter, were inserted in subpanniculus pockets in each rat. The next day, 10-Gy of radiation from a clinical accelerator was targeted at the implants. Simvastatin (15 mg/kg/day) was administered by oral gavage in the experimental group, while animals in the control group received water. At 12 weeks post-implantation, peri-implant capsules were harvested and examined histologically and by real-time polymerase chain reaction. The average capsular thickness was 371.2 μm in the simvastatin group and 491.2 μm in the control group. The fibrosis ratio was significantly different, with 32.33% in the simvastatin group and 58.44% in the control group (P < 0.001). Connective tissue growth factor (CTGF) and transforming growth factor (TGF)-β1 gene expression decreased significantly in the simvastatin group compared to the control group (P < 0.001). This study shows that simvastatin reduces radiation-induced capsular fibrosis around silicone implants in rats. This finding offers an alternative therapeutic strategy for reducing capsular fibrosis and contracture after implant-based breast reconstruction.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Al-Ghazal SK / 2000 / The psychological impact of immediate rather than delayed breast reconstruction / Eur J Surg Oncol 26:17~19
Kronowitz SJ / 2009 / Radiation therapy and breast reconstruction : a critical review of the literature / Plast Reconstr Surg 124:395~408
Whitfield GA / 2009 / Incidence of severe capsular contracture following implant-based immediate breast reconstruction with or without postoperative chest wall radiotherapy using 40 gray in 15 fractions / Radiother Oncol 90:141~147
Rosato RM / 1994 / Radiation therapy as a cause of capsular contracture / Ann Plast Surg 32:342~345
Spano A / 2008 / Reduction of capsular thickness around silicone breast implants by zafirlukast in rats / Eur Surg Res 41:8~14
Kronowitz SJ / 2009 / Radiation therapy and breast reconstruction : a critical review of the literature / Plast Reconstr Surg 124:395~408
Whitfield GA / 2009 / Incidence of severe capsular contracture following implant-based immediate breast reconstruction with or without postoperative chest wall radiotherapy using 40 gray in 15 fractions / Radiother Oncol 90:141~147
Rosato RM / 1994 / Radiation therapy as a cause of capsular contracture / Ann Plast Surg 32:342~345
Spano A / 2008 / Reduction of capsular thickness around silicone breast implants by zafirlukast in rats / Eur Surg Res 41:8~14
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