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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 635 - 640 (6page)
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A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERSCoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because of progressive respiratory failure. Urinary protein excretion steadily increased for a microalbumin to creatinine ratio of 538.4 mg/g Cr and a protein to creatinine ratio of 3,025.8 mg/g Cr. The isotope dilution mass spectrometry traceable serum creatinine level increased to 3.0 mg/dL. We performed a kidney biopsy 8 weeks after the onset of symptoms. Acute tubular necrosis was the main finding, and proteinaceous cast formation and acute tubulointerstitial nephritis were found. There were no electron dense deposits observed with electron microscopy. We could not verify the virus itself by in situ hybridization and confocal microscopy (MERS-CoV costained with dipeptidyl peptidase 4). The viremic status, urinary virus excretion, and timely kidney biopsy results should be investigated with thorough precautions to reveal the direct effects of MERS-CoV with respect to renal complications.
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참고문헌 (20)
참고문헌 신청
Memish ZA / 2013 / Family cluster of Middle East respiratory syndrome coronavirus infections / N Engl J Med 368:2487~2494
Guery B / 2013 / Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus : a report of nosocomial transmission / Lancet 381:2265~2272
Zaki AM / 2012 / Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia / N Engl J Med 367:1814~1820
Poissy J / 2014 / MERS-CoV Biology Group. Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases / J Clin Virol 61:275~278
Raj VS / 2013 / Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC / Nature 495:251~254
Guery B / 2013 / Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus : a report of nosocomial transmission / Lancet 381:2265~2272
Zaki AM / 2012 / Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia / N Engl J Med 367:1814~1820
Poissy J / 2014 / MERS-CoV Biology Group. Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases / J Clin Virol 61:275~278
Raj VS / 2013 / Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC / Nature 495:251~254
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