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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 585 - 589 (5page)
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초록· 키워드
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The aim of this study was to investigate whether the omega-3 fatty acids help to improve erectile function in an atherosclerosis-induced erectile dysfunction rat model. A total of 20 male Sprague-Dawley rats at age 8 weeks were divided into three groups: Control group (n = 6, untreated sham operated rats), Pathologic group (n = 7, untreated rats with chronic pelvic ischemia [CPI]), and Treatment group (n = 7, CPI rats treated with omega-3 fatty acids). For the in vivo study, electrical stimulation of the cavernosal nerve was performed and erectile function was measured in all groups. Immunohistochemical antibody staining was performed for transforming growth factor beta-1 (TGF-β1), endothelial nitric oxide synthase (eNOS), and hypoxia inducible factor 1-alpha (HIF-1α). In vivo measurement of erectile function in the Pathologic group showed significantly lower values than those in the Control group, whereas the Treatment group showed significantly improved values in comparison with those in the Pathologic group. The results of western blot analysis revealed that systemically administered omega-3 fatty acids ameliorated the cavernosal molecular environment. Our study suggests that omega-3 fatty acids improve intracavernosal pressure and have a beneficial role against pathophysiological consequences such as fibrosis or hypoxic damage on a CPI rat model, which represents a structural erectile dysfunction model.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Benet AE / 1995 / The epidemiology of erectile dysfunction / Urol Clin North Am 22:699~709
Rosen RC / 2005 / Epidemiology of erectile dysfunction: the role of medical comorbidities and lifestyle factors / Urol Clin North Am 32:403~417
Russell S / 2005 / Lower urinary tract symptoms and erectile dysfunction: epidemiology and treatment in the aging man / Curr Urol Rep 6:445~453
Aboseif SR / 1989 / Erectile response to acute and chronic occlusion of the internal pudendal and penile arteries / J Urol 141:398~402
Ritskes-Hoitinga J / 1988 / Atherosclerosis in the rat / Artery 16:25~50
Rosen RC / 2005 / Epidemiology of erectile dysfunction: the role of medical comorbidities and lifestyle factors / Urol Clin North Am 32:403~417
Russell S / 2005 / Lower urinary tract symptoms and erectile dysfunction: epidemiology and treatment in the aging man / Curr Urol Rep 6:445~453
Aboseif SR / 1989 / Erectile response to acute and chronic occlusion of the internal pudendal and penile arteries / J Urol 141:398~402
Ritskes-Hoitinga J / 1988 / Atherosclerosis in the rat / Artery 16:25~50
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