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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 525 - 534 (10page)
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초록· 키워드
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Prolonged P-wave duration has been observed in diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to elucidate the possible mechanisms. A rat model of type 2 diabetes mellitus (T2DM) was used. P-wave durations were obtained using surface electrocardiography and sizes of the left atrium were determined using echocardiography. Cardiac inward rectifier K+ currents (Ik1), Na+ currents (INa), and action potentials were recorded from isolated left atrial myocytes using patch clamp techniques. Left atrial tissue specimens were analyzed for total connexin-40 (Cx40) and connexin-43 (Cx43) expression levels on western-blots. Specimens were also analyzed for Cx40 and Cx43 distribution and interstitial fibrosis by immunofluorescent and Masson trichrome staining, respectively. The mean P-wave duration was longer in T2DM rats than in controls; however, the mean left atrial sizes of each group of rats were similar. The densities of Ik1 and INa were unchanged in T2DM rats compared to controls. The action potential duration was longer in T2DM rats, but there was no significant difference in resting membrane potential or action potential amplitude compared to controls. The expression level of Cx40 protein was significantly lower, but Cx43 was unaltered in T2DM rats. However, immunofluorescent labeling of Cx43 showed a significantly enhanced lateralization. Staining showed interstitial fibrosis was greater in T2DM atrial tissue. Prolonged P-wave duration is not dependent on the left atrial size in rats with T2DM. Dysregulation of Cx40 and Cx43 protein expression, as well as fibrosis, might partly account for the prolongation of P-wave duration in T2DM.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Huxley RR / 2011 / Meta-analysis of cohort and case-control studies of type 2 diabetes mellitus and risk of atrial fibrillation / Am J Cardiol 108:56~62
Yazici M / 2007 / The effect of diabetes mellitus on the P-wave dispersion / Circ J 71:880~883
Ariyarajah V / 2005 / Correlation of left atrial size with p-wave duration in interatrial block / Chest 128:2615~2618
Dagli N / 2008 / Are maximum P wave duration and P wave dispersion a marker of target organ damage in the hypertensive population? / Clin Res Cardiol 97:98~104
Goyal SB / 2001 / Electromechanical dysfunction of the left atrium associated with interatrial block / Am Heart J 142:823~827
Yazici M / 2007 / The effect of diabetes mellitus on the P-wave dispersion / Circ J 71:880~883
Ariyarajah V / 2005 / Correlation of left atrial size with p-wave duration in interatrial block / Chest 128:2615~2618
Dagli N / 2008 / Are maximum P wave duration and P wave dispersion a marker of target organ damage in the hypertensive population? / Clin Res Cardiol 97:98~104
Goyal SB / 2001 / Electromechanical dysfunction of the left atrium associated with interatrial block / Am Heart J 142:823~827
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