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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 463 - 466 (4page)
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Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
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참고문헌 (11)
참고문헌 신청
Siegel R / 2014 / Cancer statistics, 2014 / CA Cancer J Clin 64:9~29
Uramoto H / 2014 / Recurrence after surgery in patients with NSCLC / Transl Lung Cancer Res 3:242~249
Klaus A / 2008 / Wnt signalling and its impact on development and cancer / Nat Rev Cancer 8:387~398
Komiya Y / 2008 / Wnt signal transduction pathways / Organogenesis 4:68~75
Reya T / 2005 / Wnt signalling in stem cells and cancer / Nature 434:843~850
Uramoto H / 2014 / Recurrence after surgery in patients with NSCLC / Transl Lung Cancer Res 3:242~249
Klaus A / 2008 / Wnt signalling and its impact on development and cancer / Nat Rev Cancer 8:387~398
Komiya Y / 2008 / Wnt signal transduction pathways / Organogenesis 4:68~75
Reya T / 2005 / Wnt signalling in stem cells and cancer / Nature 434:843~850
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