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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 293 - 302 (10page)
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Objective. To estimate the cardiovascular (CV) and gastrointestinal (GI) risks of etoricoxib in the treatment of osteoarthritis (OA) compared to a placebo and other non-steroidal anti-inflammatory drugs (NSAIDs). Methods. A systematic review of randomized, controlled trials (RCTs) of etoricoxib were performed. Bayesian network meta-analysis was used over a duration of 12 weeks. The incidence of CV and GI events for a duration ≥26 weeks were also tabulated and presented using descriptive statistics. Results. From this search, 10 studies were identified. Of these, 6 and 5 RCTs that measured the CV and GI events at 12 weeks were included in meta-analysis. They showed that etoricoxib did not increase the CV events compared to the placebo or NSAIDs during the 12 week period (odds ratio [OR]=0.59 compared to celecoxib, OR=0.89 with ibuprofen, OR=0.70 with placebo, and OR=2.16 with naproxen). The risk of GI events was comparable to that of most comparators, with the exception of naproxen, which had a significantly lower risk of GI events (OR=0.18) during the 12 week period. For a duration ≥26 weeks, the incidence of CV and GI events with etoricoxib increased with increasing duration. Conclusion. Etoricoxib is an alternative short-term treatment option for OA, showing comparable CV and GI complications to other NSAIDs. Nevertheless, further studies will be needed to elucidate the long-term safety of etoricoxib in the treatment of OA.
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참고문헌 (37)
참고문헌 신청
Elders MJ / 2000 / The increasing impact of arthritis on public health / J Rheumatol Suppl 60:6~8
Hochberg MC / 2012 / American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee / Arthritis Care Res (Hoboken) 64:465~474
Jordan KM / 2003 / EULAR Recommendations 2003 : an evidence based approach to the management of knee osteoarthritis : Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials(ESCISIT) / Ann Rheum Dis 62:1145~1155
McAlindon TE / 2014 / OARSI guidelines for the non-surgical management of knee osteoarthritis / Osteoarthritis Cartilage 22:363~388
Jevsevar DS / 2013 / Treatment of osteoarthritis of the knee: evidence-based guideline / J Am Acad Orthop Surg 21:571~576
Hochberg MC / 2012 / American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee / Arthritis Care Res (Hoboken) 64:465~474
Jordan KM / 2003 / EULAR Recommendations 2003 : an evidence based approach to the management of knee osteoarthritis : Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials(ESCISIT) / Ann Rheum Dis 62:1145~1155
McAlindon TE / 2014 / OARSI guidelines for the non-surgical management of knee osteoarthritis / Osteoarthritis Cartilage 22:363~388
Jevsevar DS / 2013 / Treatment of osteoarthritis of the knee: evidence-based guideline / J Am Acad Orthop Surg 21:571~576
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