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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 143 - 148 (6page)
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초록· 키워드
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Objective. We investigated the association of platelet distribution width (PDW) and mean platelet volume (MPV) with disease activity indices of ankylosing spondylitis (AS) in patients whose laboratory results or medical conditions would not affect PDW and MPV levels. Methods. We analysed demographic and laboratory data of 88 patients with AS. On the same day as the laboratory tests were done, we assessed AS disease activity using the Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Patients Global Score and Ankylosing Spondylitis Disease Activity Score (ASDAS), including erythrocyte sedimentation rate (ESR) (ASDAS-ESR) and C-reactive protein (CRP) (ASDAS-CRP). The association was analyzed by linear regression. Results. The median age of 88 patients was 38.0 years and the median length of observation was 5.5 years. The median platelet count was 266,500.0/μL, the median PDW was 10.7 fL and the median MPV 9.6 fL. The median ESR was 19.0 mm/hr and CRP was 2.5 mg/L. Among acute reactants, only CRP was negatively correlated with MPV, but not PDW (r=−0.218, p＜0.041). However, both PDW and MPV were not significantly correlated with any disease activity index of AS. On multivariate linear regression analysis, only the length of observation was significantly correlated with MPV (β=0.224, p＜0.044). Conclusion. PDW and MPV were not potent surrogate markers to reflect AS activity, with potential confounding strictly controlled, to affect MPV and PDW levels.
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참고문헌 (28)
참고문헌 신청
Sieper J / 2016 / New treatment targets for axial spondyloarthritis / Rheumatology (Oxford) 55(suppl 2):ii38~ii42
Dougados M / 1999 / Clinical relevance of C-reactive protein in axial involvement of ankylosing spondylitis / J Rheumatol 26:971~974
Pedersen SJ / 2011 / ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNFα inhibitors / Ann Rheum Dis 70:1375~1381
Garrett S / 1994 / A new approach to defining disease status in ankylosing spondylitis : the Bath Ankylosing Spondylitis Disease Activity Index / J Rheumatol 21:2286~2291
Calin A / 1994 / A new approach to defining functional ability in ankylosing spondylitis : the development of the Bath Ankylosing Spondylitis Functional Index / J Rheumatol 21:2281~2285
Dougados M / 1999 / Clinical relevance of C-reactive protein in axial involvement of ankylosing spondylitis / J Rheumatol 26:971~974
Pedersen SJ / 2011 / ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNFα inhibitors / Ann Rheum Dis 70:1375~1381
Garrett S / 1994 / A new approach to defining disease status in ankylosing spondylitis : the Bath Ankylosing Spondylitis Disease Activity Index / J Rheumatol 21:2286~2291
Calin A / 1994 / A new approach to defining functional ability in ankylosing spondylitis : the development of the Bath Ankylosing Spondylitis Functional Index / J Rheumatol 21:2281~2285
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