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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 11 - 15 (5page)
이용수
초록· 키워드
오류제보하기
Romosozumab, a specific inhibitor of sclerostin, is a unique approach to therapy for postmenopausal osteoporosis and related disorders. The elucidation of sclerostin deficiency as the molecular defect of syndromes of high bone mass with normal quality, and the pivotal role of sclerostin as a mediator of osteoblastic activity and bone formation, provided the platform for the evaluation of inhibitors of sclerostin to activate bone formation. An extensive preclinical program and 2 large fracture endpoint trials with romosozumab, a sclerostin-binding antibody, have been completed. This review will highlight the results of those studies and describe the current status of romosozumab as a potential therapy for osteoporosis.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
NIH consensus development panel on osteoporosis prevention, diagnosis, and therapy / 2001 / Osteoporosis prevention, diagnosis, and therapy / J Am Med Assoc 285:785~795
van Lierop AH / 2017 / Sclerostin deficiency in humans / Bone 96:51~62
Li X / 2008 / Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength / J Bone Miner Res :860~869
Ominsky MS / 2017 / Effects of sclerostin antibodies in animal models of osteoporosis / Bone 96:63~75
Ominsky MS / 2017 / Romosozumab improves bone mass and strength while maintaining bone quality in ovariectomized cynomolgus monkeys / J Bone Miner Res 32:788~801
van Lierop AH / 2017 / Sclerostin deficiency in humans / Bone 96:51~62
Li X / 2008 / Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength / J Bone Miner Res :860~869
Ominsky MS / 2017 / Effects of sclerostin antibodies in animal models of osteoporosis / Bone 96:63~75
Ominsky MS / 2017 / Romosozumab improves bone mass and strength while maintaining bone quality in ovariectomized cynomolgus monkeys / J Bone Miner Res 32:788~801
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