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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,368 - 1,375 (8page)
- DOI
- 10.13000/JFMSE.2021.12.33.6.1368
이용수
초록· 키워드
오류제보하기
Lincomycin is a drug known to be effective in treating streptococcus aureus as it inhibits the protein synthesis by binding to 50S ribosomal subunits. However, in the test method registered in Korean Food Code the Maximum Residue Limit (MRL) is set to be 0.1 mg/kg regardless of the kinds or body areas of fishes. In addition, only analysis using high performance liquid chromatography mass spectrometry (HPLC-MS/MS) was presented, so we developed analytical methods to detect trace concentrations of serum and muscle in the olive flounder using HPLC-MS/MS. The analyte was quantified in the positive ion mode using multiple reaction monitoring (MRM). Samples were extracted with methanol and then Hydrphilic-Liphophilic Balance (HLB) was used for purification. Matrix-matched calibration (MMC) presented linearity with the correlation coefficient (r²)>0.99, analyzed at 0.5~50 ng/g concentration. The limit of quantitation (LOQ) of muscle was 0.5 ng/g and recovery was 89.33%(n=9, Intra-day). The LOQ of serum was 0.5 ng/g and recovery was 97.40%(n=9, Intra-day) which were suitable for CODEX guideline. This analysis would be appropriate for the study of lincomycin residues and pharmacokinetics in olive flounder.
목차
Abstract
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 연구 결과
Ⅳ. 고찰
Ⅴ. 결론
References
참고문헌 (12)
참고문헌 신청
CAC/GL 71-2009, Codex Alimentarius Committee
Collignon P / 2008 / Guide to Antimicrobial Use in Animals / Blackwell Publishing :44~58
Commission Decision 2002/657/EC, Implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results
KFDA / Ministry of food and drug safety
Kim YJ / 2019 / Determination of epidemiological Cut-off Values for lincomycin and tylosin in Streptococcus parauberis :233~233
Collignon P / 2008 / Guide to Antimicrobial Use in Animals / Blackwell Publishing :44~58
Commission Decision 2002/657/EC, Implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results
KFDA / Ministry of food and drug safety
Kim YJ / 2019 / Determination of epidemiological Cut-off Values for lincomycin and tylosin in Streptococcus parauberis :233~233
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