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논문 기본 정보

자료유형
학술저널
저자정보
Kim Jeonghun (성균관대학교) Chun Sang Hun (성균관대학교) Amornkitbamrung Lunjakorn (Chulalongkorn University) Song Chanyoung (성균관대학교) 육지수 (성균관대학교) Ahn So Yeon (성균관대학교) Kim Byung Woo (성균관대학교) 임용택 (성균관대학교) OHBYUNG-KEUN (서강대학교) 엄숭호 (성균관대학교)
저널정보
나노기술연구협의회 Nano Convergence Nano Convergence Vol.7 No.6
발행연도
2020.1
수록면
1 - 9 (9page)

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Gold particles have been widely used in the treatment of prostate cancer due to their unique optical properties, such as their light-heat conversion in response to near-infrared radiation. Due to well-defined synthesis mechanisms and simple manufacturing methods, gold particles have been fabricated in various sizes and shapes. However, the low photothermal transduction efficiency in their present form is a major obstacle to practical and therapeutic uses of these particles. In the current work, we present a silica-coated gold nanoparticle cluster to address the therapeutic limit of single gold nanoparticles (AuNPs) and use its photothermal effect for treatment against PC-3, a typical prostate cancer. Due to its specific nanostructure, this gold nanocluster showed three times higher photothermal transduction efficiency than free single AuNPs. Moreover, while free single particles easily clump and lose optical properties, this silica-coated cluster form remained stable for a longer time in a given medium. In photothermal tests under near-infrared radiation, the excellent therapeutic efficacy of gold nanoclusters, referred to as AuNC@SiO 2 , was observed in a preclinical sample. Only the samples with both injected nanoclusters followed by photothermal treatment showed completely degraded tumors after 15 days. Due to the unique intrinsic biocompatibility and higher therapeutic effect of these silica-coated gold nanoclusters, they may contribute to enhancement of therapeutic efficacy against prostate cancer.

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