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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 72 - 78 (7page)
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초록· 키워드
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Objective: The aim of the study is to assess feasibility of using aortic valve calcification volume (AVCV) as a surrogate marker for aortic stenosis (AS) by studying the correlation between AVCV on contrast enhanced CT (CECT) and severity of AS using echocardiographic indices. Materials and Methods: Ninety-four patients with AS, who underwent CECT and echocardiography as part of pre-transcatheter aortic valve implantation assessment were analysed. AVC was quantified on CECT using methodology validated by Bischoff et al. Severity of AS was categorized by echocardiography indices [transaortic jet velocity, mean pressure gradient, aortic valve area (AVA) by continuity and planimetry equations, indexed AVA to body surface area and dimensionless index (DI)]. Results: Moderate to strong correlation was found between AVCV with transaortic jet velocity (rs=0.397, p<0.001), peak pressure gradient (rs=0.410, p<0.001) and mean pressure gradient (rs=0.381, p<0.001). There was statistically significant correlation between AVCV with indexed AVA (rs=-0.225, p<0.001) and DI (rs=-0.644 p<0.001) but not with AVA by continuity equation (rs=-0.024, p<0.826) and by planimetry (rs=-0.185, p<0.158). Although not statistically significant, patients with higher degree of AS were noted to have higher AVCV burden on CECT. Conclusion: Quantification of AVCV using CECT is a potential complementary marker for grading of AS severity. AVCV has additive value when there is discrepancy between clinical and echocardiography examinations or discordant echocardiographic indices due to variation in techniques of imaging and small body size in Asian population.
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참고문헌 (16)
참고문헌 신청
Singapore demographics / Worldometer Web site
Leon MB / 2010 / Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery / N Engl J Med 363:1597~1607
Bevan GH / 2019 / Mortality due to aortic stenosis in the United States, 2008-2017 / JAMA 321:2236~2238
Sacchi S / 2018 / Doppler assessment of aortic stenosis: a 25-operator study demonstrating why reading the peak velocity is superior to velocity time integral / Eur Heart J Cardiovasc Imaging 19:1380~1389
Bonow RO / 2008 / 2008 focused update incorporated into the ACC/AHA 2006guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease):endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons / Circulation 118:e523~e661
Leon MB / 2010 / Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery / N Engl J Med 363:1597~1607
Bevan GH / 2019 / Mortality due to aortic stenosis in the United States, 2008-2017 / JAMA 321:2236~2238
Sacchi S / 2018 / Doppler assessment of aortic stenosis: a 25-operator study demonstrating why reading the peak velocity is superior to velocity time integral / Eur Heart J Cardiovasc Imaging 19:1380~1389
Bonow RO / 2008 / 2008 focused update incorporated into the ACC/AHA 2006guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease):endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons / Circulation 118:e523~e661
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