지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 93 - 100 (8page)
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초록· 키워드
오류제보하기
Background: Blood viscosity (BV) is a measurement of the intrinsic resistance of blood to flow, and high BV increases thromboembolic risk. Although laboratory documentation of clopidogrel resistance has been shown to predict an increased risk of cardiovascular events in patients with ischemic stroke, there is no evidence that cytochrome P450 2C19 (CYP2C19) polymorphisms in clopidogrel-treated patients influence BV after ischemic stroke. Methods: Patients with ischemic stroke or transient ischemic attack within 7 days of symptom onset from April 2018 to October 2019 were included. Patients were classified into the good genotype group for clopidogrel metabolism (ultrarapid or extensive metabolizer) and poor genotype group (intermediate/unknown or poor metabolizer) based on their CYP2C19 genotype status. A scanning capillary-tube viscometer was used to assess whole BV, and patients were divided into decreased BV and increased BV groups. Results: The final analyses included 174 patients (109 men and 65 women) with a mean age of 66.4±11.2 years. The good genotype was found in 44% of patients with decreased systolic BV (SBV) and 27% of those with increased SBV (P=0.029), suggesting that BV changes were related to the CYP2C19 genotype for clopidogrel metabolism. Binary logistic regression analysis showed that CYP2C19 genotype status (P=0.024) and baseline SBV (P<0.001) were significantly associated with decreased BV. The good genotype for clopidogrel metabolism was associated with decreased BV in patients with ischemic stroke treated with clopidogrel. Conclusion: The present results indicate that the effect of clopidogrel treatment on ischemic stroke prevention could be modulated not only by inhibition of platelet function but also by changes in the hemorheological profile.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Furukawa K / 2016 / Increased blood viscosity in ischemic stroke patients with small artery occlusion measured by an electromagnetic spinning sphere viscometer / J Stroke Cerebrovasc Dis 25:2762~2769
Pop GA / 2002 / The clinical significance of whole blood viscosity in(cardio)vascular medicine / Neth Heart J 10:512~516
Song SH / 2017 / Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke / BMC Neurol 17:20
Kwaan HC / 2010 / Role of plasma proteins in whole blood viscosity : a brief clinical review / Clin Hemorheol Microcirc 44:167~176
Mury P / 2017 / Higher daily physical activity level is associated with lower RBC aggregation in carotid artery disease patients at high risk of stroke / Front Physiol 8:1043
Pop GA / 2002 / The clinical significance of whole blood viscosity in(cardio)vascular medicine / Neth Heart J 10:512~516
Song SH / 2017 / Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke / BMC Neurol 17:20
Kwaan HC / 2010 / Role of plasma proteins in whole blood viscosity : a brief clinical review / Clin Hemorheol Microcirc 44:167~176
Mury P / 2017 / Higher daily physical activity level is associated with lower RBC aggregation in carotid artery disease patients at high risk of stroke / Front Physiol 8:1043
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