지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Adalimumab, tumor necrosis factor-alpha inhibitor, has been used for the treatment of various immune-mediated inflammatory diseases including psoriasis. However, it may cause hepatitis B virus (HBV) reactivation. A 64 years-old male patient presented with plaque psoriasis for 15 years’ duration. After receiving phototherapy and oral methotrexate for 6 months, adalimumab treatment was started due to inefficacy. He has been regularly follow-up at the local clinic as a chronic HBV carrier. Before adalimumab treatment, HBV DNA level was 1.15×102 IU/ml. However, the level gradually increased to 2.07×104 IU/ml at 6 months and 2.02×105 IU/ml at 12 months of treatment. Adalimumab was discontinued and he was referred to a hepatologist. He was identified as an HBV inactive carrier, and has been observed with 6-month follow-up. This case report highlights the importance of screening and preventing HBV reactivation in patients using immunosuppressive drugs.
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참고문헌 (12)
참고문헌 신청
G Lapadula / 2014 / Adalimumab in the treatment of immune-mediated diseases / Int J Immunopathol Pharmacol 27:33~48
Ramiro S / 2014 / Safety of synthetic and biological DMARDs : a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis / Ann Rheum Dis 73:529~535
Caporali R / 2010 / Safety of tumor necrosis factor alpha blockers in hepatitis B virus occult carriers(hepatitis B surface antigen negative/anti-hepatitis B core antigen positive)with rheumatic diseases / Arthritis Care Res(Hoboken) 62:749~754
임선영 / 2019 / The epidemiology of hepatitis B virus infection in Korea / The Korean Journal of Internal Medicine 34(5):945~953
J Sanz-Bueno / 2015 / Risk of reactivation of hepatitis B virus infection in psoriasis patients treated with biologics: a retrospective analysis of 20cases from the BIOBADADERM database / Actas Dermosifiliogr 106:477~482
Ramiro S / 2014 / Safety of synthetic and biological DMARDs : a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis / Ann Rheum Dis 73:529~535
Caporali R / 2010 / Safety of tumor necrosis factor alpha blockers in hepatitis B virus occult carriers(hepatitis B surface antigen negative/anti-hepatitis B core antigen positive)with rheumatic diseases / Arthritis Care Res(Hoboken) 62:749~754
임선영 / 2019 / The epidemiology of hepatitis B virus infection in Korea / The Korean Journal of Internal Medicine 34(5):945~953
J Sanz-Bueno / 2015 / Risk of reactivation of hepatitis B virus infection in psoriasis patients treated with biologics: a retrospective analysis of 20cases from the BIOBADADERM database / Actas Dermosifiliogr 106:477~482
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