지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
There has been increasing awareness of the association between psoriasis and lymphoma. There is a hypothesis that the evolution of psoriasis into cutaneous T-cell lymphoma is the result of chronic immune stimulation and lymphoproliferation. Moreover, misdiagnosis and/or therapies including immunosuppressant, and immunomodulating agents may explain the high risk of developing lymphoma in psoriatic patients. We report a 48-year-old woman with a 25-year history of psoriasis. She had been diagnosed as psoriasis with typical histopathological features. Although the therapeutic response to cyclosporine and methotrexate was good at the early stage of psoriasis, the clinical manifestation of mycosis fungoides (MF) were observed as the symptoms worsened. After repetitive skin biopsies, epidermotropism of atypical lymphocytic cells were observed, and monoclonality was detected in the TCR gene rearrangement. Neither internal organ involvement nor lymphadenopathy was detected by computed tomography and bone marrow biopsy. The patient was diagnosis with MF as T4N0M0B0 in TNMB staging.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Chiesa Fuxench ZC / 2016 / The Risk of Cancer in Patients With Psoriasis : A Population-Based Cohort Study in the Health Improvement Network / JAMA Dermatol 152:282~290
Asgari MM / 2017 / Malignancy rates in a large cohort of patients with systemically treated psoriasis in a managed care population / J Am Acad Dermatol 76:632~638
Wong HK / 2011 / Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma(mycosis fungoides and Sezary syndrome) / Br J Haematol 155:150~166
Donigan JM / 2016 / The temporal association between cutaneous T-cell lymphoma and psoriasis : implications for common biologic processes / J Eur Acad Dermatol Venereol 30:e31~e32
Papathemeli D / 2018 / Mycosis fungoides in patients with psoriasis : an ongoing issue / Eur J Dermatol 28:235~236
Asgari MM / 2017 / Malignancy rates in a large cohort of patients with systemically treated psoriasis in a managed care population / J Am Acad Dermatol 76:632~638
Wong HK / 2011 / Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma(mycosis fungoides and Sezary syndrome) / Br J Haematol 155:150~166
Donigan JM / 2016 / The temporal association between cutaneous T-cell lymphoma and psoriasis : implications for common biologic processes / J Eur Acad Dermatol Venereol 30:e31~e32
Papathemeli D / 2018 / Mycosis fungoides in patients with psoriasis : an ongoing issue / Eur J Dermatol 28:235~236
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