지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 47 - 52 (6page)
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초록· 키워드
오류제보하기
Purpose: Thromboelastography (TEG) was investigated for the diagnosis of coagulopathy compared with traditional coagulation tests, in association with disease severity in patients with severe sepsis or septic shock. Methods: Retrospective data was collected from a single center between January 25th to March 24th, 2016. There were 18 patients with severe sepsis or septic shock admitted to intensive care units included in this study. Laboratory tests including TEG were performed at admission. Disease severity was measured using the Simplified Acute Physiology Score III, Sequential Organ Failure Assessment score, and the level of lactate. Results: There were 18 patients (61% males; median age, 60.5 years) who were diagnosed with severe sepsis, or septic shock requiring a norepinephrine infusion (n = 10, 55.6%). Of these, 4 patients had traditional coagulation tests, and TEG profiles which confirmed hypercoagulability. Eight patients had follow-up tests 48 hours post-admission with a Sequential Organ Failure Assessment score of 6.5 (3-9.5) at admission, decreasing to 4 (2-11) after 48 hours (although not significantly lower), however, the lactate level decreased statistically significantly from 2.965 at admission, to 1.405 mmol/L after 48 hours (p < 0.05). The TEG profiles tended to normalize after 48 hours compared with admission, but there was no statistically significant difference. Conclusion: Coagulopathy with severe sepsis or septic shock patients can be life-threatening, therefore it is important to diagnose coagulopathy early and precisely. TEG can be a feasible tool to confirm coagulopathy with traditional coagulation tests.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ostrowski SR / 2013 / Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality : A prospective study / J Crit Care 28(3):317.e1~317.e11
Schouten M / 2008 / Inflammation, endothelium, and coagulation in sepsis / J Leukoc Biol 83(3):536~545
Collins PW / 2006 / Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls / Br J Haematol 135(2):220~227
Gonano C / 2006 / Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis / Crit Care 10(6):R160
Daudel F / 2009 / Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis : A prospective cohort study / Crit Care 13(2):R42
Schouten M / 2008 / Inflammation, endothelium, and coagulation in sepsis / J Leukoc Biol 83(3):536~545
Collins PW / 2006 / Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls / Br J Haematol 135(2):220~227
Gonano C / 2006 / Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis / Crit Care 10(6):R160
Daudel F / 2009 / Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis : A prospective cohort study / Crit Care 13(2):R42
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