지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 182 - 194 (13page)
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The prevalence and progression of non-alcoholic fatty liver disease (NAFLD) is mediated via several factors correlating with hepatic necroinflammation (adipokines/cytokines). This study was performed to analyze the level of inflammatory markers according to the presence of NAFLD and to identify related nutritional factors. A total of 80 adults were classified into 2 groups (healthy and NAFLD), and their body composition, blood tests, and eating habits were evaluated. In addition, inflammatory markers (adiponectin, high-sensitivity C-reactive protein [CRP], and tumor necrosis factor-alpha [TNF-α]), nutrient intake status, and dietary quality were compared. The quality of diet was assessed according to the nutrient adequacy ratio and the mean adequacy ratio (MAR). The NAFLD group had a higher body mass index (p < 0.001) than the healthy group and also carried significantly higher CRP levels (p < 0.001) but lower adiponectin (p = 0.001). TNF-α levels increased significantly with fatty liver grade (p = 0.023). The NAFLD group showed significantly higher intake of energy, carbohydrates, iron, sodium, vitamin A and saturated fatty acids, but significantly lower intake of zinc and vitamin E than the healthy group. The MAR values were slightly higher in the NAFLD group but without any significant difference. The levels of adiponectin and vitamin E showed a significant inverse correlation (p < 0.05). Nutritional management of NAFLD patients is important, and the intake of antioxidant and anti-inflammatory nutrients such as zinc and vitamin E should be emphasized.
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참고문헌 (39)
참고문헌 신청
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Clark JM / 2003 / Nonalcoholic fatty liver disease : an underrecognized cause of cryptogenic cirrhosis / JAMA 289:3000~3004
Utzschneider KM / 2006 / Review : the role of insulin resistance in nonalcoholic fatty liver disease / J Clin Endocrinol Metab 91:4753~4761
Yoneda M / 2007 / High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis(NASH)and also of the severity of fibrosis in NASH / J Gastroenterol 42:573~582
Targher G / 2006 / Relationship between high-sensitivity C-reactive protein levels and liver histology in subjects with non-alcoholic fatty liver disease / J Hepatol 45:879~881
Clark JM / 2003 / Nonalcoholic fatty liver disease : an underrecognized cause of cryptogenic cirrhosis / JAMA 289:3000~3004
Utzschneider KM / 2006 / Review : the role of insulin resistance in nonalcoholic fatty liver disease / J Clin Endocrinol Metab 91:4753~4761
Yoneda M / 2007 / High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis(NASH)and also of the severity of fibrosis in NASH / J Gastroenterol 42:573~582
Targher G / 2006 / Relationship between high-sensitivity C-reactive protein levels and liver histology in subjects with non-alcoholic fatty liver disease / J Hepatol 45:879~881
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