Sorafenib-induced Pancreatic Pseudocyst in a Patient with Advanced Hepatocellular Carcinoma: a Rare Adverse Event

Dae-ha Kim; Minkoo Kim; Hyung Joon Yim; Sang Jun Suh; Young Kul Jung

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자료유형: 학술저널

저자정보: Dae-ha Kim (Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University) Minkoo Kim (Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University) Hyung Joon Yim (Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University) Sang Jun Suh (Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University) Young Kul Jung (Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University)

저널정보: 대한간암학회 Journal of Liver Cancer Journal of Liver Cancer Vol.19 No.2

발행연도: 2019.1

수록면: 154 - 158 (5page)

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A 54-year old man diagnosed with advanced hepatocellular carcinoma began treatment with sorafenib. After 3 weeks of treatment, he complained of abdominal pain and nausea. Abdominal sonography showed multiple hepatic lesions only. Serum amylase and lipase levels were 35 U/L and 191 U/L, respectively. The patient was diagnosed with sorafenib-induced acute pancreatitis. After 10 days of discontinuing sorafenib he still complained of nausea and loss of appetite. Esophagogastroduodenoscopy showed a large bulging lesion, which was suspected to cause extrinsic compression on the high body of the gastric anterior wall. Computed tomography scan revealed a cystic lesion, 8.3 cm in size, in the pancreatic tail, suggesting a pancreatic pseudocyst. After the withdrawal of sorafenib, systemic chemotherapy with Adriamycin and cisplatin was administered. Four months after the discontinuation of sorafenib, the size of the pancreatic pseudocyst decreased from 8.3 cm to 3 cm. The patient's symptoms were also relieved.

#Advanced hepatocellular carcinoma #Sorafenib #Adverse event #Pancreatic pseudocyst #Pancreatitis

참고문헌 (13)

참고문헌 신청

Liu L / 2006 / Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5 / Cancer Res 66:11851~11858

Llovet JM / 2008 / Sorafenib in advanced hepatocellular carcinoma / N Engl J Med 359:378~390

Li M / 2007 / Acute pancreatitis associated with sorafenib / South Med J 100:909~911

Pezzilli R / 2010 / Tyrosine kinase inhibitors and acute pancreatitis / JOP 11:291~293

Amar S / 2007 / Sorafenib-induced pancreatitis / Mayo Clin Proc 82:521

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