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Management of malignant diseases in elderly patients has been a global clinical issue because of increased life expectancy worldwide. Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. Surgical resection is the only potentially curative treatment for pancreatic cancer. Resection of the pancreas, either by pancreaticoduodenectomy (PD) or laparoscopic pancreaticoduodenectomy (LPD) is a complex surgical procedure with a high rate of morbidity and mortality. However, mortality rates after pancreatic surgery have dropped to less than 2-5% at experienced centers. Whereas, complication rates are high, reaching at least 30% in many centers. Mortality also increases proportionally with age viz. 6.7% of patients aged 65-69 years, 9.3% of patients aged 70-79 years, and 15.5% of patients aged 80 years or older. The present review article delineates clinical outcomes along with safety, morbidity and mortality after PD or LPD in elderly, especially in octogenarian patients.
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참고문헌 (52)
참고문헌 신청
Siegel RL / 2017 / Colorectal cancer statistics, 2017 / CA Cancer J Clin 6:177~193
Gleisner AL / 2014 / Time-related changes in the prognostic significance of the total number of examined lymph nodes in node-negative pancreatic head cancer / J Surg Oncol 110:858~863
Winter JM / 2012 / Survival after resection of pancreatic adenocarcinoma : results from a single institution over three decades / Ann Surg Oncol 19:169~175
Lee DY / 2014 / Outcomes of pancreaticoduodenectomy for pancreatic malignancy in octogenarians : an American College of Surgeons national surgical quality improvement program analysis / Am J Surg 207:540~548
Lightner AM / 2004 / Pancreatic resection in the elderly / J Am Coll Surg 198:697~706
Gleisner AL / 2014 / Time-related changes in the prognostic significance of the total number of examined lymph nodes in node-negative pancreatic head cancer / J Surg Oncol 110:858~863
Winter JM / 2012 / Survival after resection of pancreatic adenocarcinoma : results from a single institution over three decades / Ann Surg Oncol 19:169~175
Lee DY / 2014 / Outcomes of pancreaticoduodenectomy for pancreatic malignancy in octogenarians : an American College of Surgeons national surgical quality improvement program analysis / Am J Surg 207:540~548
Lightner AM / 2004 / Pancreatic resection in the elderly / J Am Coll Surg 198:697~706
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