지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Somatostatin receptors (SSTR) are overexpressed in various tumors including neuroendocrine tumors. In-111 Octreoscan or Ga-68 DOTATOC positron emission tomography/computed tomography (PET/CT) showed these SSTR expressing tumors in whole body of patients. Ga-68 DOTATOC PET/CT has a better sensitivity and resolution than In-111 Octreoscan with single photon emission computed tomography (SPECT)/CT.. The indications of Ga-68 DOTATOC PET/CT are 1) staging: detect sites of primary and metastasis, 2) re-staging: follow-up of patients with known disease to detect residual, recurrent or progressive disease, 3) prognosis & management decisions: determine SSTR status & select patients with SSTR radionuclide therapy, and 4) monitor the response to therapy. Nuclear medicine treatments for neuroendocrine tumors with radioisotope labeling on the somatostatin receptor targeting peptide (peptide receptor radionuclide therapy, PRRT) were conducted in Europe, Australia, and other countries for over 20 years. Eligible patients to be effective to PRRT using Lu-177 DOTATATE can be pre-screened by confirming the expression of somatostatin receptor on tumors using Octreoscan or Ga-68 DOTATOC PET/CT prior to treatment. This pair of molecular targeted treatment and companion diagnostics, so called molecular theranostics makes PRRT a good example for a precision medicine. A multinational clinical trial with the Lu-177 DOTATATE treatment (Lutathera) showed a significant progression free survival over the control group and Ministry of Food and Drug Safety in Korea approved Lutathera. Some doctors are treating patients who are refractory to Lu-177 using Ac-225, an alpha-emitter therapy in Germany and India. The high therapeutic effect of the alpha emitting radionuclides will lead the future of nuclear medicine therapy.
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등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Shi W / 1998 / Localization of neuroendocrine tumours with [111In] DTPA-octreotide scintigraphy(Octreoscan) : a comparative study with CT and MR imaging / QJM 91:295~301
Wong KK / 2010 / Incremental value of 111-in pentetreotide SPECT/CT fusion imaging of neuroendocrine tumors / Acad Radiol 17:291~297
Buchmann I / 2007 / Comparison of 68GaDOTATOC PET and 111In-DTPAOC(Octreoscan)SPECT in patients with neuroendocrine tumours / Eur J Nucl Med Mol Imaging 34:1617~1626
Geijer H / 2013 / Somatostatin receptor PET/CT in neuroendocrine tumours : update on systematic review and meta-analysis / Eur J Nucl Med Mol Imaging 40:1770~1780
Hicks RJ / 2010 / Use of molecular targeted agents for the diagnosis, staging and therapy of neuroendocrine malignancy / Cancer Imaging 10(Spec no A):S83~S91
Wong KK / 2010 / Incremental value of 111-in pentetreotide SPECT/CT fusion imaging of neuroendocrine tumors / Acad Radiol 17:291~297
Buchmann I / 2007 / Comparison of 68GaDOTATOC PET and 111In-DTPAOC(Octreoscan)SPECT in patients with neuroendocrine tumours / Eur J Nucl Med Mol Imaging 34:1617~1626
Geijer H / 2013 / Somatostatin receptor PET/CT in neuroendocrine tumours : update on systematic review and meta-analysis / Eur J Nucl Med Mol Imaging 40:1770~1780
Hicks RJ / 2010 / Use of molecular targeted agents for the diagnosis, staging and therapy of neuroendocrine malignancy / Cancer Imaging 10(Spec no A):S83~S91
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