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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 399 - 410 (12page)
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BACKGROUND: High-fat diet-induced obesity is one of the major cause of chronic renal failure. This obesity-related renal failure is mainly caused by inflammatory processes. However, the role of the major anti-inflammatory cytokine interleukin (IL)-10 has not been researched intensively. METHODS: To evaluate the effect of IL-10 deficiency on obesity-related renal failure, the in vivo study was carried with four animal groups; (1) Low-fat dieted C57BL/6 mice, (2) Low-fat dieted IL-10 knockout (KO) mice, (3) High‐fat dieted C57BL/6 mice and (4) High‐fat dieted IL-10 KO mice group. The analysis was carried with blood/urine chemistry, H&E, Oil-Red-O, periodic acid-Schiff and Masson’s trichrome staining immunohistochemistry and real-time PCR methods. RESULTS: At week 12, high‐fat dieted IL-10 KO mice showed 1) severe lipid accumulation in kidneys, cholesterol elevation (in total, serum kidney) and low-density lipoprotein increasion through the SCAP-SREBP2-LDLr pathway; (2) serious histopathologic alterations showing glomerulosclerosis, tubulointerstitial fibrosis and immune cell infiltration; (3) increased pro‐inflammatory cytokines and chemokines expression; (4) enhanced renal fibrosis; and (5) serious functional failure with high serum creatinine and BUN and proteinuria excretion compared to other groups. CONCLUSION: IL-10 deficiency aggravates renal inflammation, fibrosis and functional failure in high-fat dieted obese mice, thus IL-10 therapy could be applied to obesity-related chronic renal failure.
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참고문헌 (43)
참고문헌 신청
Iglesias P / 2010 / Adipose tissue in renal disease : clinical significance and prognostic implications / Nephrol Dial Transplant 25:2066~2077
Martins A / 2015 / Lipotoxicity and kidney / Port J Nephrol Hypert 29:306~315
Cordeiro AC / 2010 / Abdominal fat deposition is associated with increased inflammation, protein-energy wasting and worse outcome in patients undergoing haemodialysis / Nephrol Dial Transplant 25:562~568
Liu L / 2014 / Roles of chronic low-grade inflammation in the development of ectopic fat deposition / Mediators Inflamm 2014:418185
de Waal Malefyt R / 1991 / Interleukin 10(IL-10)inhibits cytokine synthesis by human monocytes : an autoregulatory role of IL-10 produced by monocytes / J Exp Med 174:1209~1220
Martins A / 2015 / Lipotoxicity and kidney / Port J Nephrol Hypert 29:306~315
Cordeiro AC / 2010 / Abdominal fat deposition is associated with increased inflammation, protein-energy wasting and worse outcome in patients undergoing haemodialysis / Nephrol Dial Transplant 25:562~568
Liu L / 2014 / Roles of chronic low-grade inflammation in the development of ectopic fat deposition / Mediators Inflamm 2014:418185
de Waal Malefyt R / 1991 / Interleukin 10(IL-10)inhibits cytokine synthesis by human monocytes : an autoregulatory role of IL-10 produced by monocytes / J Exp Med 174:1209~1220
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