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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 415 - 429 (15page)
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초록· 키워드
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BACKGROUND: Three-dimensional (3D) printed bone tissue engineering scaffolds have been widely used in research and clinical applications. b-TCP is a biomaterial commonly used in bone tissue engineering to treat bone defects, and its multifunctionality can be achieved by co-doping different metal ions. Magnesium doping in biomaterials has been shown to alter physicochemical properties of cells and enhance osteogenesis. METHODS: A series of Mg-doped TCP scaffolds were manufactured by using cryogenic 3D printing technology and sintering. The characteristics of the porous scaffolds, such as microstructure, chemical composition, mechanical properties, apparent porosity, etc., were examined. To further study the role of magnesium ions in simultaneously inducing osteogenesis and angiogenesis, human bone marrow mesenchymal stem cells (hBMSCs) and human umblical vein endothelial cells (HUVECs) were cultured in scaffold extracts to investigate cell proliferation, viability, and expression of osteogenic and angiogenic genes. RESULTS: The results showed that Mg-doped TCP scaffolds have the advantages of precise design, interconnected porous structure, and similar compressive strength to natural cancellous bone. hBMSCs and HUVECs exhibit high proliferation rate, cell morphology and viability in a certain amount of Mg2?. In addition, this concentration of magnesium can also increase the expression levels of osteogenic and angiogenic biomarkers. CONCLUSION: A certain concentration of magnesium ions plays an important role in new bone regeneration and reconstruction. It can be used as a simple and effective method to enhance the osteogenesis and angiogenesis of bioceramic scaffolds, and support the development of biomaterials and bone tissue engineering scaffolds.
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참고문헌 (58)
참고문헌 신청
de Sousa CA / 2018 / Bone augmentation using autogenous bone versus biomaterial in the posterior region of atrophic mandibles : a systematic review and meta-analysis / J Dent 76:1~8
Al-Nawas B / 2014 / Augmentation procedures using bone substitute materials or autogenous bone—a systematic review and meta-analysis / Eur J Oral Implantol 7:S219~S234
Barone A / 2011 / Morbidity associated with iliac crest harvesting in the treatment of maxillary and mandibular atrophies : a 10-year analysis / J Oral Maxillofac Surg 69:2298~2304
Calori GM / 2014 / Incidence of donor site morbidity following harvesting from iliac crest or RIA graft / Injury 45:S116~S120
Sponer P / 2018 / Comparative study on the application of mesenchymal stromal cells combined with tricalcium phosphate scaffold into femoral bone defects / Cell Transplant 27:1459~1468
Al-Nawas B / 2014 / Augmentation procedures using bone substitute materials or autogenous bone—a systematic review and meta-analysis / Eur J Oral Implantol 7:S219~S234
Barone A / 2011 / Morbidity associated with iliac crest harvesting in the treatment of maxillary and mandibular atrophies : a 10-year analysis / J Oral Maxillofac Surg 69:2298~2304
Calori GM / 2014 / Incidence of donor site morbidity following harvesting from iliac crest or RIA graft / Injury 45:S116~S120
Sponer P / 2018 / Comparative study on the application of mesenchymal stromal cells combined with tricalcium phosphate scaffold into femoral bone defects / Cell Transplant 27:1459~1468
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