지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Osteoporosis is a skeletal disorder characterized by compromised bone strength resulting in a predisposition to fracture. Osteoporosis-related fractures can lead to pain, disability, and increased healthcare costs. This study aimed to explore different pharmacological treatments for osteoporosis. Various treatments are used to prevent and treat osteoporosis, particularly in postmenopausal women and elderly men, but the approach needs to be individually tailored. Bisphosphonates are most commonly used to treat osteoporosis. Bisphosphonates and denosumab are mainly used during the initial phase of therapy for most patients with osteoporosis, including those with a high risk of fracture. In younger postmenopausal women, menopausal hormone therapy (including tibolone) and selective estrogen receptor modulators may be considered as alternatives for fracture prevention. Parathyroid hormone therapy is recommended for osteoporosis treatment in elderly patients with an increased risk of multiple vertebral fractures. Dual energy X-ray absorptiometry (DXA) is the mainstay for monitoring the treatment response, and clinicians may consider alternative treatments if a significant decrease in bone mineral density is detected (using DXA or bone turnover markers) or if recurrent fractures occur during treatment. For postmenopausal women undergoing long-term bisphosphonate treatment, the risk of fracture should be reassessed after 3 to 5 years, and a “drug holiday” should be considered if the risk of fracture is low-to-moderate. Therapy should be continued for patients who continue to exhibit a high risk of fracture, or alternatively, switching to other treatments may be considered.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
NIH Consensus Development Panel on Osteoporosis Preven-tion / 2001 / Diagnosis, and Therapy. Osteoporosis prevention, diag-nosis, and therapy / JAMA 285:785~795
Riggs BL / 2002 / Sex steroids and the construction and conservation of the adult skeleton / Endocr Rev 23:279~302
Korean Society for Bone and Mineral Resaerch / Physicianʼs guide for diagnosis and treatment of osteoporosis 2015
Barrionuevo P / 2019 / Efficacy of pharmacological therapies for the prevention of fractures in postmenopausal women : a network meta-analysis / J Clin Endocrinol Metab 104:1623~1630
Eastell R / 2019 / Pharmacological management of osteoporosis in postmenopausal women : an Endocrine Society Clinical Practice Guideline / J Clin Endocrinol Metab 104:1595~1622
Riggs BL / 2002 / Sex steroids and the construction and conservation of the adult skeleton / Endocr Rev 23:279~302
Korean Society for Bone and Mineral Resaerch / Physicianʼs guide for diagnosis and treatment of osteoporosis 2015
Barrionuevo P / 2019 / Efficacy of pharmacological therapies for the prevention of fractures in postmenopausal women : a network meta-analysis / J Clin Endocrinol Metab 104:1623~1630
Eastell R / 2019 / Pharmacological management of osteoporosis in postmenopausal women : an Endocrine Society Clinical Practice Guideline / J Clin Endocrinol Metab 104:1595~1622
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