Thermo- and pH-Responsive CeF3 Nanocrystals/HPC–PAA Complex Nanogel and Its Drug Release Behavior

Ben Liu; Qiusheng Song; Qiancheng Zhang; Haihong Ma; Ziwen Zhang; Dapeng Wang

추천

검색

자료유형: 학술저널

저자정보: Ben Liu (Hefei University of Technology) Qiusheng Song (Hefei University of Technology) Qiancheng Zhang (Hefei University of Technology) Haihong Ma (Hefei University of Technology) Ziwen Zhang (Hefei University of Technology) Dapeng Wang (Hefei University of Technology)

저널정보: 성균관대학교 성균나노과학기술원 NANO NANO Vol.14 No.8

발행연도: 2019.1

수록면: 90 - 99 (10page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

In this study, a kind of novel rare-earth nanocrystals/hydroxypropylcellulose–poly (acrylic acid) (HPC–PAA) complex fluorescent nanogel, its responsive behavior to environmental temperature and pH value were reported. For preparation, with HPC being used as template, HPC–PAA nanogel was first synthesized by polymerization and crosslinking reaction of acrylic acid (AA) in water solution. In the process, a redox initiator, which composed of ammonium persulfate (APS) and N,N,N′,N′-tetramethylethylenediamine (TEMED), was used to initiate the reaction. Then, the as-prepared nanogel reacted with Ce(NO3)3 and NH4F solution successively, and a novel CeF3 nanocrystals/HPC–PAA complex nanogel was fabricated. The microstructure of the nanogel was characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), Thermogravimetric (TG) and Transmission electron microscopy (TEM). The environmental sensitivity of the nanogel was investigated by photoluminescence (PL) and UV–Visible spectrophotometer (UV–Vis). The thermo- and pH-sensitive fluorescence were studied by PL at various temperatures and pH values; besides, the behavior of drug loading and release was researched by PL with a famous antibiotic of Ibuprofen as model drug. The results show that the PL intensity of the nanogel was largely affected by environmental temperature, or content of Ibuprofen loaded in the nanogel. The as-prepared nanogel can be used as useful sensitive material to detect temperature and pH value change, and drug loading or release property of Ibuprofen can be detected by PL emission of the nanogels conveniently.

#Hydroxypropylcellulose #polyacrylic acid #CeF3 nanocrystals #thermo- and pH-sensitive #drug release

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!