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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Cancer remains a leading cause of death, despite multimodal treatment approaches. Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. Cancer cells incapacitate the normal cell-mediated immune system by expressing immune modulation ligands such as programmed death (PD) ligand 1, the B7 molecule, or secreting activators of immune modulators. Chimeric antigen receptor (CAR) T cells were originally designed to target cancer cells. Engineered approaches allow CAR T cells, which possess a simplified yet specific receptor, to be easily activated in limited situations. CAR T cell treatment is a derivative of the antigen-antibody reaction and can be applied to various diseases. In this review, the current successes of CAR T cells in cancer treatment and the therapeutic potential of CAR T cells are discussed.
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참고문헌 (55)
참고문헌 신청
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Lawn SD / 2001 / Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection / Clin Microbiol Rev 14:753~777
Parkin J / 2001 / An overview of the immune system / Lancet 357:1777~1789
Andersen MH / 2006 / Cytotoxic T cells / J Invest Dermatol 126:32~41
Smith-Garvin JE / 2009 / T cell activation / Annu Rev Immunol 27:591~619
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