지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 265 - 274 (10page)
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초록· 키워드
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Inflammatory bowel disease (IBD) is a common diarrheal illness with gastrointestinal and extraintestinal manifestations and complications. The most common infectious complication associated with IBD is <i>Clostridioides difficile</i> infection (CDI). Active IBD predisposes to CDI due to alterations in the gut microbiome. <i>C. difficile</i> is a toxin producing bacterium leading to worsening of underlying IBD, increasing the risk of IBD treatment failure and an increased risk of hospitalization and surgery. Since the symptoms of CDI overlap with those of an IBD flare; it is prudent to recognize that the diagnosis of CDI is challenging and diagnostic tests (nucleic-acid and toxin-based assays) should be interpreted in context of symptoms and test performance. First line treatments for management of CDI in IBD include vancomycin or fidaxomicin. Recurrence prevention strategies should be implemented to mitigate recurrent CDI risk. One needs to monitor IBD disease progression and manage immunosuppression. The risk of recurrent CDI after a primary infection is higher in IBD compared to non-IBD patients. Microbiota restoration therapies are effective to prevent recurrent CDI in IBD patients. This review summarizes the epidemiology, pathophysiology, diagnostic testing, outcomes and management of both CDI and IBD, in CDI complicating IBD.
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등록된 정보가 없습니다.
참고문헌 (69)
참고문헌 신청
Kaplan GG / 2015 / The global burden of IBD : from 2015 to 2025 / Nat Rev Gastroenterol Hepatol 12:720~727
Franzosa EA / 2019 / Gut microbiome structure and metabolic activity in inflammatory bowel disease / Nat Microbiol 4:293~305
Khanna S / 2017 / Management of Clostridium difficile infection in inflammatory bowel disease : expert review from the Clinical Practice Updates Committee of the AGA Institute / Clin Gastroenterol Hepatol 15:166~174
Hanada Y / 2018 / Non-Clostridium difficile bacterial infections are rare in patients with flares of inflammatory bowel disease / Clin Gastroenterol Hepatol 16:528~533
Leffler DA / 2015 / Clostridium difficile infection / N Engl J Med 373:287~288
Franzosa EA / 2019 / Gut microbiome structure and metabolic activity in inflammatory bowel disease / Nat Microbiol 4:293~305
Khanna S / 2017 / Management of Clostridium difficile infection in inflammatory bowel disease : expert review from the Clinical Practice Updates Committee of the AGA Institute / Clin Gastroenterol Hepatol 15:166~174
Hanada Y / 2018 / Non-Clostridium difficile bacterial infections are rare in patients with flares of inflammatory bowel disease / Clin Gastroenterol Hepatol 16:528~533
Leffler DA / 2015 / Clostridium difficile infection / N Engl J Med 373:287~288
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