지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 255 - 264 (10page)
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초록· 키워드
오류제보하기
With the overspread use of measurement of serum levels of anti-tumor necrosis factor (TNF) agents (therapeutic drug monitoring, TDM), new therapeutic strategies have been used in the management of Crohn’s disease (CD). Different targets are correlated with increased levels of circulating drugs. Recent evidence demonstrated that higher serum levels of anti-TNF agents may be associated to better outcomes in perianal fistulizing CD (PFCD). Overall, patients with healed fistulas had higher serum levels of infliximab and adalimumab as compared to those with active drainage. This was demonstrated in some cohort studies, in induction and maintenance, in adults and children with PFCD. In this narrative review, authors summarize current evidence on the use of serum level measurement of anti-TNF agents and its correlation with perianal fistula healing in CD patients. Data on the use of TDM in PFCD is discussed in detail. The retrospective design of the studies and the lack of objective parameters to measure fistula healing are the main limitations of published data. Prospective studies, with central reading of objective radiological parameters, such as pelvic magnetic resonance imaging scores, can improve the level of evidence on the possible advantages of TDM in perianal fistula in CD and are warranted.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Gomollón F / 2017 / 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016 : part 1 : diagnosis and medical management / J Crohns Colitis 11:3~25
Peyrin-Biroulet L / 2010 / The natural history of adult Crohn’s disease in population-based cohorts / Am J Gastroenterol 105:289~297
Ng SC / 2018 / Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century : a systematic review of population-based studies / Lancet 390:2769~2778
Tang LY / 2006 / Are perineal and luminal fistulas associated in Crohn’s disease? A population-based study / Clin Gastroenterol Hepatol 4:1130~1134
Tozer PJ / 2011 / Review article: medical, surgical and radiological management of perianal Crohn’s fistulas / Aliment Pharmacol Ther 33:5~22
Peyrin-Biroulet L / 2010 / The natural history of adult Crohn’s disease in population-based cohorts / Am J Gastroenterol 105:289~297
Ng SC / 2018 / Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century : a systematic review of population-based studies / Lancet 390:2769~2778
Tang LY / 2006 / Are perineal and luminal fistulas associated in Crohn’s disease? A population-based study / Clin Gastroenterol Hepatol 4:1130~1134
Tozer PJ / 2011 / Review article: medical, surgical and radiological management of perianal Crohn’s fistulas / Aliment Pharmacol Ther 33:5~22
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