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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 247 - 251 (5page)
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초록· 키워드
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Azathioprine is widely used for the treatment of Crohn’s disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrahepatic portal hypertension but no evidence of cirrhosis or chronic liver disease. Patients with idiopathic NCPH present with symptoms of portal hypertension such as thrombocytopenia, splenomegaly and esophageal varices. We report a case of idiopathic NCPH in a 51-year-old male patient with CD who had been taking azathioprine for 5 years. He was admitted due to esophageal variceal bleeding along with splenomegaly and thrombocytopenia. Evaluation of cirrhosis or chronic liver disease showed normal-range results as estimated by FibroScan evaluation, laboratory examination for autoimmune hepatitis or viral hepatitis, and liver biopsy. This case may suggest the need for careful monitoring for manifestations of portal hypertension in Asian patients with inflammatory bowel disease receiving thiopurine treatment.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Torres J / 2017 / Crohn’s disease / Lancet 389:1741~1755
Kaplan GG / 2017 / Understanding and preventing the global increase of inflammatory bowel disease / Gastroenterology 152:313~321
Pola S / 2014 / Non-cirrhotic portal hypertension due to 6-mercaptopurine use for Crohn’s disease / Dig Dis Sci 59:1642~1644
Riggio O / 2016 / Idiopathic noncirrhotic portal hypertension : current perspectives / Hepat Med 8:81~88
Dooremont D / 2013 / Azathioprine induced serious portal hypertension : a case series of three IBD patients and review of the literature / Acta Gastroenterol Belg 76:342~346
Kaplan GG / 2017 / Understanding and preventing the global increase of inflammatory bowel disease / Gastroenterology 152:313~321
Pola S / 2014 / Non-cirrhotic portal hypertension due to 6-mercaptopurine use for Crohn’s disease / Dig Dis Sci 59:1642~1644
Riggio O / 2016 / Idiopathic noncirrhotic portal hypertension : current perspectives / Hepat Med 8:81~88
Dooremont D / 2013 / Azathioprine induced serious portal hypertension : a case series of three IBD patients and review of the literature / Acta Gastroenterol Belg 76:342~346
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