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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 403 - 415 (13page)
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This paper reports a study on developing of a protein detection biochip based on interdigitated array electrodes (IDAEs) capacitive immunosensor. The protein after being preconcentrated in a detection region will be selectively captured and detected by the capacitive immunosensor. Using electrical impedance spectroscopy operated at high-frequency in the range of 100 kHz–1 MHz, the capacitance of the gold electrode is determined and the antibody surface modification steps can be also monitored. The experiment results show the capacitance changes in accordance with the adding biochemical layer on gold electrodes for each step of the antibody surface modification. In particular, the total impedance operated at 1 MHz frequency has been seen to change from 2.1 kΩ of bare chip (before antibody surface modification) to 8 kΩ after antibody surface modification process while the serial capacitance is recorded to reduce steadily from 450 pF to 55 pF. Also, the efficiency of protein chip was investigated by implementing the measurement of 10 µM BSA with and without preconcentration process. The measurement results have shown the sensitivity increasing significantly after the protein is preconcentrated in this chip. The results demonstrate high efficiency of protein detection can be achieved by operating high frequency capacitive measurement on IDAEs capacitive immunosensor.
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참고문헌 (37)
참고문헌 신청
Hudelist, G. / 2004 / Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue / Breast Cancer Res. Treat 86:281~291
Yaziji, H. / 2008 / Consensus recommendations on estrogen receptor testing in breast cancer by immunohistochemistry / Appl. Immunohistochem. Mol. Morphol 16:513~520
Powers, A.D. / 2014 / Protein analytical assays for diagnosing, monitoring, and choosing treatment for cancer patients / J. Healthcare Eng 3:503~534
Veskimäe, K. / 2016 / Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry / Tumor Biol 37:11991~11999
Schmitt, M. / 2006 / Procedures for the quantitative protein determination of urokinase and its inhibitor, PAI-1, in human breast cancer tissue extracts by ELISA / Methods Mol. Med 120:245~265
Yaziji, H. / 2008 / Consensus recommendations on estrogen receptor testing in breast cancer by immunohistochemistry / Appl. Immunohistochem. Mol. Morphol 16:513~520
Powers, A.D. / 2014 / Protein analytical assays for diagnosing, monitoring, and choosing treatment for cancer patients / J. Healthcare Eng 3:503~534
Veskimäe, K. / 2016 / Assessment of PARP protein expression in epithelial ovarian cancer by ELISA pharmacodynamic assay and immunohistochemistry / Tumor Biol 37:11991~11999
Schmitt, M. / 2006 / Procedures for the quantitative protein determination of urokinase and its inhibitor, PAI-1, in human breast cancer tissue extracts by ELISA / Methods Mol. Med 120:245~265
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