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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 8 - 19 (12page)
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To present a more physiologically relevant microenvironment for cells, hydrogel-based threedimensional culture platforms have been widely adopted. As noted by multiple pioneering reports, the neural cells are sensitive with the change of mechanical properties of the microenvironment. Therefore, in the context of brain tissue engineering and brain-on-a-chip, there is a need to consider the brain-tissue-specific mechanical properties of hydrogels. In this review, we overview the influence the mechanical properties of hydrogel on the behavior of brain tissue cells. For this purpose, in addition to the stiffness, the viscoelasticity and degradability of hydrogels are considered to be mechanical cues, and we summarize how those mechanical properties can affect cell behavior, such as viability, proliferation, differentiation, and spreading. Consideration of the brain tissue-specific mechanical microenvironment may guide the design of 3D cell culture platforms for brain tissue engineering and brain- on-a-chip.
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참고문헌 (72)
참고문헌 신청
Rousseau, F. / 1994 / Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia / Nature 371:252~254
Edmondson, R. / 2014 / Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors / Assay Drug Dev. Technol 12:207~218
Jo, R. / 2018 / Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development / Theranostics 8:5259~5275
Ravi, M. / 2015 / 3D Cell Culture Systems: Advantages and Applications: a Review / J. Cell. Physiol 230:16~26
Caliari, S. R. / 2016 / A practical guide to hydrogels for cell culture / Nat. Methods 13:405~414
Edmondson, R. / 2014 / Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors / Assay Drug Dev. Technol 12:207~218
Jo, R. / 2018 / Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development / Theranostics 8:5259~5275
Ravi, M. / 2015 / 3D Cell Culture Systems: Advantages and Applications: a Review / J. Cell. Physiol 230:16~26
Caliari, S. R. / 2016 / A practical guide to hydrogels for cell culture / Nat. Methods 13:405~414
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