Gallstones, Cholecystectomy and the Risk of Hepatobiliary and Pancreatic Cancer: A Nationwide Population-based Cohort Study in Korea

Dan Huang; Joonki Lee; Nan Song; 조수영; Sunho Choe; 신애선

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자료유형: 학술저널

저자정보: Dan Huang (Seoul National University) Joonki Lee (Seoul National University) Nan Song (Seoul National University) 조수영 (Seoul National University) Sunho Choe (Seoul National University College of Medicine Seoul Korea) 신애선 (서울대학교)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제25권 제3호

발행연도: 2020.1

수록면: 164 - 172 (9page)

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Several epidemiological studies suggest a potential association between gallstones or cholecystectomy and hepatobiliary and pancreatic cancers (HBPCs). The aim of this study was to evaluate the risk of HBPCs in patients with gallstones or patients who underwent cholecystectomy in the Korean population. A retrospective cohort was constructed using the National Health Insurance Service-National Sample Cohort (NHIS-NSC). Gallstones and cholecystectomy were defined by diagnosis and procedure codes and treated as time-varying covariates. Hazard ratios (HRs) in relation to the risk of HBPCs were estimated by Cox proportional hazard models. Among the 704,437 individuals who were included in the final analysis, the gallstone prevalence was 2.4%, and 1.4% of individuals underwent cholecystectomy. Between 2002 and 2015, 487 and 189 individuals developed HBPCs in the gallstone and cholecystectomy groups, respectively. A significant association was observed between gallstones and all HBPCs (HR 2.16; 95% CI 1.92-2.42) and cholecystectomy and all HBPCs (HR 2.03; 95% CI 1.72-2.39). However, when 1-, 3-, and 5-year lag periods were applied, the HBPC and subsites risk approached zero. A significant association was observed between cholecystectomy and intrahepatic bile duct cancer (IBDC) (HR 2.68; 95% CI 1.63-4.40). When 1-, 3- and 5-year lag periods were applied, the IBDC risk after cholecystectomy was 2.86-fold (95% CI 1.68-4.85), 2.92-fold (95% CI 1.51-5.64), and 4.08-fold (95% CI 1.94-8.61) higher, respectively, than that in the comparison group. In conclusion, gallstone diagnosis and cholecystectomy seem to correlate with HBPCs, especially cholecystectomy and IBDC.

#Gallstones #Cholecystectomy #Liver neoplasms #Biliary tract neoplasms #Pancreatic neoplasms

참고문헌 (35)

참고문헌 신청

장예림 / 2013 / Changes in Demographic Features of Gallstone Disease: 30 Years of Surgically Treated Patients / Gut and Liver 7(6):719~724

Laura M. Stinton / 2012 / Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer / Gut and Liver 6(2):172~187

Surveillance Research Program / SEER*Stat software [Computer Program]. Version. 8.3.5

Almond HR / 1973 / Bile acid pools, kinetics and biliary lipid composition before and after cholecystectomy / N Engl J Med 289:1213~1216

Lowenfels AB / 1985 / Gallstones and risk of gallbladder cancer / J Natl Cancer Inst 75:77~80

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