Efficacy of Cereal-based Oral Nutrition Supplement on Nutritional Status, Inflammatory Cytokine Secretion and Quality of Life in Cancer Patients Under Cancer Therapy

Jin-Min Kim; Sung-Gil Hong; Bum-Seok Song; Hee-Jung Sohn; Hyunwook Baik; Mi-Kyung Sung

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자료유형: 학술저널

저자정보: Jin-Min Kim (Sookmyung Women’s University) Sung-Gil Hong (Korea Atomic Energy Institute) Bum-Seok Song (Erom Institute of Life Sciences) Hee-Jung Sohn (Bundang Jesaeng Hospital) Hyunwook Baik (Bundang Jesaeng Hospital) Mi-Kyung Sung (Sookmyung Women’s University)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제25권 제1호

발행연도: 2020.1

수록면: 55 - 63 (9page)

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A rapid increase in cancer incidence accompanied by aging population requires evidence-based supportive cancer care practices. Cancer therapies often accompany adverse events which induce malnutrition and declined quality of life. We conducted an 8-week non-randomized clinical trial to evaluate efficacy of cereal-based oral nutritional supplement (ONS) intervention on nutritional status, quality of life and inflammatory responses in cancer patients undergoing cancer therapy with 5% < weight loss. The study included 34 pateints (24 in control group, 10 in intervention group) with 15 drop-outs. ONS used in this intervention contained 0.5% arabinoxylan-rich fermented rice bran powder and 5.5% black rice powder as active ingredients in a regular cereal-based formula. Results showed that ONS intervention for 8 weeks did not show significant improvement in blood biomarkers of nutritional status or patient-generated subjective global assessment scores. However, 8-week of intervention showed reduced interleukin (IL)-6 and IL-1b secretion in lipopolysaccharide-stimulated peripheral blood mononuclear cells while IL-12p70 level was increased. For health-related quality of life (HRQoL) indices, emotional functioning and fatigue symptoms were improved after 4 weeks only in the intervention group although no difference was found at week 8. These results suggest that ONS intervention may improve chronic inflammatory status and HRQoL indices (at week 4) in cancer patients receiving treatments. Key Words Food assistance, Nutritional support, Cancer, Quality of life, Malnutrition

#Food assistance #Nutritional support #Cancer #Quality of life #Malnutrition

참고문헌 (43)

참고문헌 신청

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