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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
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Objective: Familial cancer appears at a young age and its incidence is increasing. About 12%of familial ovarian cancer cases are associated with BRCA1/2 mutations (BRCAm). In thisstudy, we investigated BRCA1 methylation may predict ovarian cancer in those with a familyhistory of cancer (FHC) but without BRCA1/2 mutations (BRCAwt). Methods: Using peripheral blood DNA from 55 subjects without a history of cancer[cancer(−)] and 52 ovarian cancer patients, we examined BRCA1 promoter methylationthrough bisulfite sequencing of the promoter and expressed the results as the cumulativemethylation index. Then, we evaluated the BRCA1 promoter methylation according to BRCA1/2germline mutations. Results: BRCA1 methylation was more prevalent in the BRCAm cancer(−) group than in theBRCAwt cancer(−) group and ovarian cancer patients (p=0.031 and p=0.019, respectively). Inthe BRCAwt cancer(−) group, BRCA1 methylation was more prevalent in those with an FHCthan in those without one and in the BRCAm cancer(−) group with an FHC (p=0.001 andp<0.001, respectively). Conclusion: Our data suggest a predictive role of BRCA1 methylation profile for ovarian cancer inthose without a history of cancer but with an FHC. BRCA1 methylation has important implicationsfor diagnostic and predictive testing of those with BRCAwt cancer(−) status with FHC.
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참고문헌 (26)
참고문헌 신청
Torre LA / 2018 / Ovarian cancer statistics, 2018 / CA Cancer J Clin 68:284~296
Chen J / 2019 / High-resolution bisulfite-sequencing of peripheral blood DNA methylation in early-onset and familial risk breast cancer patients / Clin Cancer Res 25:5301~5314
Lee MV / 2017 / BRCA-associated cancers: role of imaging in screening, diagnosis, and management / Radiographics 37:1005~1023
Jones MR / 2017 / Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction / Gynecol Oncol 147:705~713
Gayther SA / 1999 / The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes / Am J Hum Genet 65:1021~1029
Chen J / 2019 / High-resolution bisulfite-sequencing of peripheral blood DNA methylation in early-onset and familial risk breast cancer patients / Clin Cancer Res 25:5301~5314
Lee MV / 2017 / BRCA-associated cancers: role of imaging in screening, diagnosis, and management / Radiographics 37:1005~1023
Jones MR / 2017 / Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction / Gynecol Oncol 147:705~713
Gayther SA / 1999 / The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes / Am J Hum Genet 65:1021~1029
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