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논문 기본 정보

자료유형
학술저널
저자정보
Peng-Yi Lee (China Medical University Hospital) Jung-Nien Lai (School of Chinese Medicine College of Chinese Medicine China Medical University) Shang-Wen Chen (China Medical University Hospital) Ying-Chun Lin (China Medical University Hospital) Lu-Ting Chiu (Management Office for Health Data China Medical University Hospital) Yu-Ting Wei (Preventive Medicine Center Taichung Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.32 No.2
발행연도
2021.1
수록면
1 - 12 (12page)

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초록· 키워드

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Objective: This study aimed to determine the effect of radiotherapy (RT) on the risk of herpeszoster (HZ) in patients with gynecological cancers via a nationwide population-based study. Methods: Based on patient data obtained from the National Health Insurance ResearchDatabase, 1928 gynecological cancer patients were identified with 1:1 matching for RT andnon-RT cohorts by age, index date, and cancer type. Another cohort consisting of 964 non cancer individuals matched was used as normal control. The incidence of HZ was comparedbetween cancer patients with and without RT. Age, comorbidities, cancer-related surgery andchemotherapy (CT), and cancer type were adjusted as confounders. Results: The risk of HZ in cancer patients was higher than that of non-cancer individuals(14.23 versus 8.34 per 1,000 person-years [PY], the adjusted hazard ratio [aHR]=1.38,p=0.044). In the cancer population, the incidence of HZ for the RT and non-RT cohorts was20.55 versus 10.23 per 1,000 PY, respectively (aHR=1.68, p=0.009). Age >50 years was anindependent factor for developing HZ. The 5-year actuarial incidence for patients receivingneither RT nor CT, RT alone, CT alone, and combined modalities was 5.4%, 6.9%, 3.7%,and 9.9%, respectively (p<0.001). In the RT cohort, the risk rose rapidly in the first year,becoming steady thereafter. Conclusion: This population-based study showed that gynecological cancer patientsreceiving RT combined with CT had the highest cumulative risk of HZ. Health careprofessionals should be aware of the potential toxicities.

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