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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
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Objective: The aim of this study is to analyze the prognostic role of lymph-vascular spaceinvasion (LVSI), evaluated in a semi-quantitative fashion on prognosis of early stage, low riskendometrial cancer (EC). Methods: We enrolled patients who underwent surgery for endometrial cancer between2003 and 2018 in two referral cancer center. All patients had endometrioid EC, G1–G2, withmyometrial invasion <50%, and no lymph-node involvement. LVSI was analyzed in a semi quantitative way, according to a 3-tiered scoring system in absent, focal and substantial. Results: Among 524 patients, any positive LVSI was found in 57 patients (10.9%) with focalLVSI (n=35, 6.7%) and substantial LVSI (n=22, 4.2%). Substantial LVSI was associated tohigher rate of G2 (p<0.001), myometrial infiltration (p=0.002) and greater tumor dimensions(p=0.014). Patients with substantial LVSI were more likely to receive adjuvant treatment(6.6% vs. 52.6%, p<0.001). The 5-year OS was 99.5% in patients with absent LVSI and 70.6%in those with substantial LVSI (p<0.001). The 5-year disease free survival (DFS) was 93.6%in patients with absent LVSI and 56.5% in those with substantial LVSI (p<0.001). The rate ofdistant failures increased from 1.8% for absent LVSI to 22.7% for substantial LVSI (p=0.002). In univariate analysis substantial LVSI was the strongest predictor of poor overall survival(hazard ratio [HR]=11.9, p=0.001). Multivariate analysis showed that substantial LVSI wasan independent predictive factor of both recurrence (HR=5.88, p=0.001) and distant failure(HR=10.6, p=0.006). Conclusions: Substantial LVSI represents the strongest independent risk factor for decreasedsurvival and distant relapse, indicating a role for potential hematogenous dissemination.
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참고문헌 (14)
참고문헌 신청
Stålberg K / 2019 / Lymphovascular space invasion as a predictive factor for lymph node metastases and survival in endometrioid endometrial cancer - a Swedish Gynecologic Cancer Group (SweGCG) study / Acta Oncol 58:1628~1633
Colombo N / 2016 / ESMO-ESGOESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up / Int J Gynecol Cancer 26:2~30
Hachisuga T / 1999 / The grading of lymphovascular space invasion in endometrial carcinoma / Cancer 86:2090~2097
Bosse T / 2015 / Substantial lymphvascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--a pooled analysis of PORTEC 1 and 2 trials / Eur J Cancer 51:1742~1750
Gitte Ørtoft / 2019 / Lymph-vascular space invasion (LVSI) as a strong and independent predictor for non-locoregional recurrences in endometrial cancer: a Danish Gynecological Cancer Group Study / Journal of Gynecologic Oncology 30(5):1~14
Colombo N / 2016 / ESMO-ESGOESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up / Int J Gynecol Cancer 26:2~30
Hachisuga T / 1999 / The grading of lymphovascular space invasion in endometrial carcinoma / Cancer 86:2090~2097
Bosse T / 2015 / Substantial lymphvascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--a pooled analysis of PORTEC 1 and 2 trials / Eur J Cancer 51:1742~1750
Gitte Ørtoft / 2019 / Lymph-vascular space invasion (LVSI) as a strong and independent predictor for non-locoregional recurrences in endometrial cancer: a Danish Gynecological Cancer Group Study / Journal of Gynecologic Oncology 30(5):1~14
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