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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 14 (14page)
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Objective: As cancer stem cells (CSCs) are considered as the origin of tumor development,recurrence, and drug resistance, we aimed to explore the mechanism related to modulatingstemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. Methods: In this study, ovarian cancer stem cells (OCSCs) induced from cell line 3AOand A2780 were enriched in serum-free medium (SFM). The effect of SURF4 on CSC-likeproperties was evaluated by sphere-forming assays, re-differentiation assays, quantitativereal-time polymerase chain reaction, flow cytometry, Western blotting, cell viability assaysand in vivo xenograft experiments. The downstream molecule participating in SURF4maintaining stemness was screened by RNA-sequencing and identified by the experiments ofgene function. Results: SURF4 was upregulated expressed in OCSCs. Knockdown of SURF4 reduced theexpression of the related stem markers (SOX2 and c-MYC), inhibited self-renewal ability,and improved the sensitivity to chemotherapeutic drugs (paclitaxel and cisplatin) in OCSCs. SURF4 knockdown also inhibited tumorigenesis in nonobese diabetic/severe combinedimmunodeficiency mice. BIRC3 expression was controlled by SURF4, and BIRC3 showedthe similar effect as SURF4 did, and BIRC3 overexpression partially recovered stem-likeproperties abolished by SURF4 knockdown. Conclusion: Our findings suggest that SURF4 possesses the ability to maintain stemness ofOCSCs via BIRC3, and may serve as a potential target in stem cell-targeted therapy forovarian cancer.
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참고문헌 (22)
참고문헌 신청
Breed C / 2019 / Ovarian tumor cell expression of claudin-4 reduces apoptotic response to paclitaxel / Mol Cancer Res 17:741~750
Meng E / 2014 / ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling / PLoS One 9:e107142
Kipps E / 2013 / Meeting the challenge of ascites in ovarian cancer : new avenues for therapy and research / Nat Rev Cancer 13:273~282
Lathia JD / 2017 / Overview of Cancer Stem Cells and Stemness for Community Oncologists / Target Oncol 12:387~399
Lapidot T / 1994 / A cell initiating human acute myeloid leukaemia after transplantation into SCID mice / Nature 367:645~648
Meng E / 2014 / ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling / PLoS One 9:e107142
Kipps E / 2013 / Meeting the challenge of ascites in ovarian cancer : new avenues for therapy and research / Nat Rev Cancer 13:273~282
Lathia JD / 2017 / Overview of Cancer Stem Cells and Stemness for Community Oncologists / Target Oncol 12:387~399
Lapidot T / 1994 / A cell initiating human acute myeloid leukaemia after transplantation into SCID mice / Nature 367:645~648
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