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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Hairong Xu (Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing) Bixing Ye (Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing) Yu Ding (Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing) Meifeng Wang (Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing) Lin Lin (Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing) Liuqin Jiang (Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.26 No.3
발행연도
2020.1
수록면
378 - 383 (6page)

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초록· 키워드

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Background/AimsIt is known that post-reflux swallow-induced peristaltic wave (PSPW) index represents the chemical clearance of the esophagus. However, few studies have explored why some reflux episodes could induce PSPW while others in the same patient could not. The purpose of this study is to investigate the characteristics of reflux episodes which could elicit PSPW. MethodsIn this study, 269 reflux episodes were detected, of which 90 with a PSPW and 179 without a PSPW. Comparisons were made between the characteristics of reflux episodes with a PSPW and without a PSPW. The characteristics were including nadir pH, pH drop, proximal extent (cm, sec), ascending velocity (cm/sec), volume clearance time, acid clearance time, percentage acidic (%), 15 to 60-minute acid burden (seconds), and 15- to 60-minute volume burden (seconds). The characteristics between the 2 groups were compared through performing Wilcoxon signed rank test. ResultsReflux episodes followed by a PSPW were significantly associated with a higher proximal extent than those without a PSPW. After the reflux episodes, higher volume clearance time and larger volume burden were more likely to trigger a PSPW. However, there were no significant differences between the 2 groups in nadir pH, pH drop, ascending velocity, acid clearance time, percentage acidic, or acid burden. ConclusionsThe role of acid seems to be less important in a reflux episode inducing a PSPW. Proximal reflux episodes are more likely to induce a PSPW. The depression of volume clearance may also be an important factor in eliciting a PSPW.
#Esophageal pH monitoring #Gastric acid reflux #Gastroesophageal reflux

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참고문헌 (14)

참고문헌 신청
Vakil N / 2006 / The Montreal definition and classification of gastroesophageal reflux disease : a global evidence-based consensus / Am J Gastroenterol 101:1900~1920 google schola Roman S / 2017 / Ambulatory reflux monitoring for diagnosis of gastro-esophageal reflux disease : update of the porto consensus and recommendations from an international consensus group / Neurogastroenterol Motil 29:1~15 google schola Frazzoni L / 2017 / Postreflux swallow-induced peristaltic wave index and nocturnal baseline impedance can link PPIresponsive heartburn to reflux better than acid exposure time / Neurogastroenterol Motil 29:e13116 google schola Frazzoni M / 2014 / Impairment of chemical clearance is relevant to the pathogenesis of refractory reflux oesophagitis / Dig Liver Dis 46:596~602 google schola Shaw MJ / 2001 / Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease / Am J Gastroenterol 96:52~57 google schola

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