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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 131 - 138 (8page)
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Study Design: Experimental animal study. Purpose: This study investigated the therapeutic effects of human breast milk stem cell (BMSC)-conditioned medium (BMSC-CM) in a model of spinal cord injury (SCI) in male Sprague-Dawley rats. Overview of Literature: SCI is one of the leading causes of disability in addition to sensory and motor impairment. So far, there have been no successful treatments for SCI. Given the positive outcomes associated with using stem cells and their derivatives as a treatment for various diseases, there is a growing interest in using them as an SCI treatment. Recent research has demonstrated that CM from stem cells has therapeutic advantages. Methods: Human BMSCs were isolated and characterized, and CM was subsequently collected. Animals received an intrathecal administration of BMSC-CM after SCI. The activity of caspase-3 was measured to assess apoptosis, and levels of tumor necrosis factor-α and interleukin-1β were measured to assess inflammation. Also, sensory and locomotor performances were assessed after SCI and BMSC-CM administration. Results: Administration of CM from BMSC reduced apoptosis and inflammation at the site of injury in a rat model of SCI (p <0.05). Motor, sensory, locomotor, and sensorimotor performances were significantly improved in rats that received BMSC-CM after SCI. Conclusions: Intrathecal administration of BMSC-CM improved recovery in a rat model of SCI.
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참고문헌 (33)
참고문헌 신청
Roselli F / 2018 / Interferons in traumatic brain and spinal cord injury : current evidence for translational application / Front Neurol 9:458
Yuan J / 2018 / Sparstolonin B attenuates spinal cord injury‑induced inflammation in rats by modulating TLR4‑trafficking / Mol Med Rep 17:6016~6022
Massetti J / 2018 / Neurocritical care for the advanced practice clinician / Springer International Publishing :269~288
Zhu Y / 2018 / Neural stem cell therapy aiming at better functional recovery after spinal cord injury / Dev Dyn 247:75~84
Kane SC / 2018 / Geriatric trauma and acute care surgery / Springer International Publishing AG :101~108
Yuan J / 2018 / Sparstolonin B attenuates spinal cord injury‑induced inflammation in rats by modulating TLR4‑trafficking / Mol Med Rep 17:6016~6022
Massetti J / 2018 / Neurocritical care for the advanced practice clinician / Springer International Publishing :269~288
Zhu Y / 2018 / Neural stem cell therapy aiming at better functional recovery after spinal cord injury / Dev Dyn 247:75~84
Kane SC / 2018 / Geriatric trauma and acute care surgery / Springer International Publishing AG :101~108
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