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논문 기본 정보

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학술저널
저자정보
김도경 (건국대학교 의과대학) Gonzales Edson LuckT (건국대학교 의과대학) 김선민 (건국대학교) 김유정 (건국대학교 의과대학) Keremkleroo Jym L. Adil (건국대학교 의과대학) 전세진 (건국대학교) 조규석 (건국대학교) 권경자 (건국대학교) 신찬영
저널정보
한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.28 No.2
발행연도
2019.1
수록면
247 - 260 (14page)

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Sociability is the disposition to interact with one another. Rodents have a rich repertoire of social behaviors and demonstrate strong sociability. Various methods have been established to measure the sociability of rodents in simple and direct ways, which includes reciprocal social interaction, juvenile social play, and three-chamber social tests. There are possible confounding factors while performing some of these tasks, such as aggression, avoidance of interaction by the stimulus mouse, exposure to a new environment, and lengthy procedures. The present study devised a method to complement these shortcomings and measure sociability as a group in the home cage setting, which prevents group-housed mice from isolation or exposure to a new environment. The home cage social test can allow high-throughput screening of social behaviors in a short amount of time. We developed two types of home cage setup: a home cage social target interaction test that measures sociability by putting the wire cage in the center area of the cage and a home cage two-choice sociability and social preference test that measures both sociability or social preference by putting cage racks at opposite sides of the cage. Interestingly, our results showed that the two types of home cage setup that we used in this study can extract abnormal social behaviors in various animal models, similar to the three-chamber assay. Thus, this study establishes a new and effective method to measure sociability or social preference that could be a complementary assay to evaluate the social behavior of mice in various setup conditions.

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