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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective: Glufosinate-containing herbicide is being used increasingly in agriculture. Its poisoning is a worldwide concern. This study assessed the ability of the Poison Severity Score (PSS), Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring systems, and Sequential Organ Failure Assessment (SOFA) score to predict mortality in intensive care unit patients poisoned with glufosinate. Methods: This was a retrospective cohort study conducted from January 2001 to January 2019. The demographic factors, hemodynamic variables, and laboratory variables were compared in survivors and non-survivors. Using multivariate logistic analysis, the data for the total population were analyzed retrospectively to determine the factors associated with mortality. Significant predictive variables, PSS, APACHE II scoring system, and SOFA score were compared by analyzing the receiver operating characteristic curves. Results: Two hundred seventy-six patients (mean age, 56 years) were enrolled in this study. Of the 276 patients, 240 (87.0%) survived, and 36 (13.0%) died. The factors associated with mortality were a decreased mean arterial blood pressure, Glasgow Coma Scale, partial pressure of arterial oxygen/fraction of inspired oxygen, HCO3 -, pH, and HCO3 -, and an increased lactate, ammonia, C-reactive protein, PSS, SOFA score, and APACHE II score. Dyspnea, use of vasopressors, and application of mechanical ventilation were associated with mortality. In multivariate analysis, Glasgow Coma Scale<9, HCO3 -<15.8 mmol/L, lactate>5.2 mmol/L, use of vasopressors, and application of mechanical ventilation were predictive of mortality. The areas under the curve and 95% confidence intervals for these indicators were 0.920 (0.834-0.981), 0.865 (0.792-0.923), and 0.824 (0.752-0.897) for the PSS, APACHE II, and SOFA, respectively. Conclusion: The PSS can be used to predict in-hospital mortality and stratify the risk among glufosinate-poisoned patients.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Logusch EW / 1991 / Inhibition of plant glutamine synthetases by substituted phosphinothricins / Plant Physiol 95:1057~1062
Mao YC / 2012 / Acute human glufosinate-containing herbicide poisoning / Clin Toxicol(Phila) 50:396~402
Matsumura N / 2001 / Glufosinate ammonium induces convulsion through Nmethyl-D-aspartate receptors in mice / Neurosci Lett 304:123~125
Hoerlein G / 1994 / Glufosinate(phosphinothricin), a natural amino acid with unexpected herbicidal properties / Rev Environ Contam Toxicol 138:73~145
Krieger RI / 2010 / Hayes’ handbook of pesticide toxicology / Academic Press
Mao YC / 2012 / Acute human glufosinate-containing herbicide poisoning / Clin Toxicol(Phila) 50:396~402
Matsumura N / 2001 / Glufosinate ammonium induces convulsion through Nmethyl-D-aspartate receptors in mice / Neurosci Lett 304:123~125
Hoerlein G / 1994 / Glufosinate(phosphinothricin), a natural amino acid with unexpected herbicidal properties / Rev Environ Contam Toxicol 138:73~145
Krieger RI / 2010 / Hayes’ handbook of pesticide toxicology / Academic Press
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